ArticleBMC pediatrics2020
Admission platelet count and indices as predictors of outcome in children with severe Sepsis: a prospective hospital-based study.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Platelet parameters as potential biomarkers for sepsis: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- Prognostic value of combined platelet and fibrinogen levels on mortality in pediatric patients with sepsis.Annals of medicine · 2026Article
- Mean Platelet Volume as a Marker of Disease Severity in Hospitalized Children With Acute Bronchiolitis.Cureus · 2026Article
- Epidemiological characteristics of Echinococcus granulosus infection in children from some sites in Xinjiang and its association with platelets.BMC infectious diseases · 2026Article
- Article
- Time series analysis between platelet counts and 60-day mortality in sepsis patients with thrombocytopenia: a retrospective cohort study.BMC infectious diseases · 2025Observational
- Prediction of 28-day mortality in patients with sepsis based on a predictive model: A retrospective cohort study.The Journal of international medical research · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Optimizing Pediatric Sepsis Diagnosis: A Narrative Review of Two Decades of Evolution from SIRS to Phoenix Consensus.Infection and drug resistance · 2025Article
- Sepsis-Associated Acute Kidney Injury in Critically Ill Children: Incidence and Outcomes.Journal of clinical medicine · 2024Article
- The Use of Platelet Count and Indices as Prognostic Factors for Mortality in Children with Sepsis.Iranian journal of medical sciences · 2024Article
- The causal relationship between blood cell indices and 28-day mortality in sepsis: a retrospective study and bidirectional Mendelian randomization analysis.BMC infectious diseases · 2024Article
- A simple nomogram for predicting the mortality of PICU patients with sepsis-associated encephalopathy: a multicenter retrospective study.Frontiers in neurology · 2024Article
- Predictive Value of Red Cell Distribution Width-to-Platelet Ratio Combined with Procalcitonin in 28-day Mortality for Patients with Sepsis.Critical care research and practice · 2024Article
- Article
- Prognostic value of APTT combined with fibrinogen and creatinine in predicting 28-Day mortality in patients with septic shock caused by acute enteric perforation.BMC surgery · 2023Observational
- Platelet indices in overweight and obese children.European journal of pediatrics · 2023Article
- Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children.Journal of pediatric intensive care · 2023Article
- Platelet Abnormalities in Children with Laboratory-Confirmed Influenza.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is still one of the main causes of infants and children mortality especially in developing, economically challenged countries with limited resources. Our objective in this study was to determine, the prognostic value of platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) in critically ill infants and children with severe sepsis, as they are readily available biomarkers, that can guide clinicians during managing of severe sepsis.
methodsSixty children were included; they were diagnosed with severe sepsis according to the international pediatric sepsis consensus conference criteria. At admission to Pediatric intensive care unit, complete blood count with platelet count and parameters (MPV, PDW and PCT) and C-reactive protein (CRP) level were determined for all children. Also, assessment of the Pediatric Risk of Mortality (PRISM III) score was done to all. These children were followed up till discharge from hospital or death. Accordingly, they were grouped into: (1) Survivor group: included 41 children. (2) Non-survivor group: included 19 children.
resultsPlatelet count and PCT were significantly lower (p < 0.001) and MPV was significantly higher in non-survivor than survivors (p = 0.004). MPV/PLT, MPV/PCT, PDW/PLT, PDW/PCT ratios were found to be significantly higher in the non-survivors than survivor (p < 0.001 in all). PCT with sensitivity = 94.74%, was the most sensitive platelet parameter for prediction of death, while MPV/PCT was the most sensitive ratio (sensitivity = 94.7%).
conclusionThrombocytopenia, platelet indices and their ratios, especially plateletcrit and MPV/PCT, are readily available, sensitive, prognostic markers, that can identify the severe sepsis patients with poorest outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.