Evidence map›Paper›PMID 32814520›Full record

ArticleGlobal health action2020

Diabetes in urban Guinea-Bissau; patient characteristics, mortality and prevalence of undiagnosed dysglycemia.

Stine Byberg, Camilla Bundesen, Frauke Rudolf, Thorny Linda Haraldsdottir, Lamine Indjai, Rui Barai, Henning Beck-Nielsen, Morten Sodemann, Dorte Møller Jensen, Morten Bjerregaard-Andersen

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Global health action, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05591339 (Diabetes Diagnosis, Management, Prevention and Education in Guinea-Bissau), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05591339 phase4active not recruitingnot on this mapstarted 2023, after this paper: background citation

Diabetes Diagnosis, Management, Prevention and Education in Guinea-Bissau

TypeinterventionalSponsorBandim Health ProjectRan2023 to 2029Enrolled200ConditionsDiabetes Mellitus, BCG Vaccination ReactionArmsBCG vaccine (two doses, 4 weeks apart), Saline placebo (Two doses, 4 weeks apart)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Stine BybergBandim Health Project, INDEPTH Network , Bissau, Guinea-Bissau.
Camilla BundesenBandim Health Project, INDEPTH Network , Bissau, Guinea-Bissau.
Frauke RudolfBandim Health Project, INDEPTH Network , Bissau, Guinea-Bissau.
Thorny Linda HaraldsdottirBandim Health Project, INDEPTH Network , Bissau, Guinea-Bissau.
Lamine IndjaiThe Diabetes Clinic, The National Diabetes Association (ANDD) , Bissau, Guinea-Bissau.
Rui BaraiThe Diabetes Clinic, The National Diabetes Association (ANDD) , Bissau, Guinea-Bissau.
Henning Beck-NielsenSteno Diabetes Center Odense, Odense University Hospital , Odense, Denmark.
Morten SodemannBandim Health Project, INDEPTH Network , Bissau, Guinea-Bissau.
Dorte Møller JensenSteno Diabetes Center Odense, Odense University Hospital , Odense, Denmark.
Morten Bjerregaard-AndersenBandim Health Project, INDEPTH Network , Bissau, Guinea-Bissau.
Bandim Health Project · GWOdense University Hospital · DKSteno Diabetes Center · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe burden of diabetes mellitus in Sub-Saharan Africa is growing rapidly, and yet the prevalence and patient characteristics are still largely unknown.

objectivesWe analyzed clinical and demographic characteristics of Type 2 diabetes (T2DM) patients attending a diabetes clinic in Guinea-Bissau from February 2008 to April 2014, and estimated the prevalence and risk factors of unknown-impaired fasting plasma glucose (FPG) and diabetes, as well as excess mortality associated with T2DM.

methodsWe characterized T2DM patients attending the national diabetes clinic in Bissau. Diabetes was diagnosed based on FPG. We matched T2DM patients 1:1 with non-diabetes community controls on age and sex to determine relevant risk factors for T2DM using logistic regression. Furthermore, we matched patients 1:6 with community controls to assess long-term survival (until February 2019) in a Cox regression using calendar time as the underlying timescale. Verbal autopsies determined the cause of death among T2DM patients and controls.

resultsThe mean age among T2DM was 50.6 (SD 11.1), and the mean FPG at first consultation was high (13.2 mmol/L (SD 5.1)). Ethnicity, family history of diabetes, hypertension, and anthropometrics differed among T2DM patients, community controls with impaired FPG, and healthy controls. Family history of diabetes (OR = 5.65, 95% CI: 3.10-10.3) and elevated waist circumference (2.33, 1.26-4.29) were significant risk factors for T2DM. 20.4% (59/289) of community controls had abnormal FPG. T2DM patients had an excess mortality hazard ratio of 3.53 (95%CI: 1.92-6.52). Deaths caused by bacterial infections, including foot ulcers, were more common among T2DM patients, compared with community controls (54% (7/13) vs. 19% (5/27) (P = 0.02)).

conclusionSeveral risk factors including were associated with T2DM in Guinea-Bissau. We found a high prevalence of elevated FPG among randomly selected community controls. In combination with higher mortality among T2DM patients, an urgent need for better treatment options and increased awareness.

Indexed as

AdultAgedBlood GlucoseCause of DeathDiabetes Mellitus, Type 2FemaleGuinea-BissauHumansMaleMiddle AgedPrevalenceRisk FactorsBlood GlucoseAfricacommunity burdenGuinea-Bissaumortalityrisk factorsType 2 diabetes mellitus

Identifiers

PMID32814520
PMCPMC7480585
OpenAlexW3053073980

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.