Trial reportJournal of the American Heart Association2020
Effect of Optimized Versus Guidelines-Based Automated External Defibrillator Placement on Out-of-Hospital Cardiac Arrest Coverage: An In Silico Trial.
Trial report in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Variation in community and ambulance care processes for out-of-hospital cardiac arrest during the COVID-19 pandemic: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Effect of Optimized Versus Guidelines-Based Automated External Defibrillator Placement on Out-of-Hospital Cardiac Arrest Coverage: An In Silico Trial.Journal of the American Heart Association · 2020Trial
- Optimizing automated external defibrillator incremental deployment to improve out-of-hospital cardiac arrest coverage: a spatial optimization study.Resuscitation plus · 2026Article
- Leveraging primary healthcare institutions for the deployment of automated external defibrillators: a geospatial optimization analysis in Deyang, China.Resuscitation plus · 2026Article
- Strategic PAD positioning: a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Cluster Analysis as a Statistical Method for Planning the Optimal Placement of Automated External Defibrillators.Journal of clinical medicine · 2025Article
- Revealing the decision-making practices in automated external defibrillator deployment: insights from Shanghai, China.BMC public health · 2025Article
- Incidence and Outcomes After Out-of-Hospital Cardiac Arrest at Train Stations in Denmark.Journal of the American Heart Association · 2024Article
- A roadmap to building first responder networks: Lessons learned and best practices from Belgium and Switzerland.Resuscitation plus · 2023Article
- Review
- Effectiveness of Cardiopulmonary Resuscitation at the Workplace.La Medicina del lavoro · 2023Observational
- Factors affecting public access defibrillator placement decisions in the United Kingdom: A survey study.Resuscitation plus · 2023Article
- Spatiotemporal Optimization for the Placement of Automated External Defibrillators Using Mobile Phone Data.ISPRS international journal of geo-information · 2023Article
- Evolution of European Resuscitation and End-of-Life Practices from 2015 to 2019: A Survey-Based Comparative Evaluation.Journal of clinical medicine · 2022Article
- Constrained Optimization for Decision Making in Health Care Using Python: A Tutorial.Medical decision making : an international journal of the Society for Medical Decision MakingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Mathematical optimization of automated external defibrillator (AED) placement may improve AED accessibility and out-of-hospital cardiac arrest (OHCA) outcomes compared with American Heart Association (AHA) and European Resuscitation Council (ERC) placement guidelines. We conducted an in silico trial (simulated prospective cohort study) comparing mathematically optimized placements with placements derived from current AHA and ERC guidelines, which recommend placement in locations where OHCAs are usually witnessed. Methods and Results We identified all public OHCAs of presumed cardiac cause from 2008 to 2016 in Copenhagen, Denmark. For the control, we computationally simulated placing 24/7-accessible AEDs at every unique, public, witnessed OHCA location at monthly intervals over the study period. The intervention consisted of an equal number of simulated AEDs placements, deployed monthly, at mathematically optimized locations, using a model that analyzed historical OHCAs before that month. For each approach, we calculated the number of OHCAs in the study period that occurred within a 100-m route distance based on Copenhagen's road network of an available AED after it was placed ("OHCA coverage"). Estimated impact on bystander defibrillation and 30-day survival was calculated by multivariate logistic regression. The control scenario involved 393 AEDs at historical, public, witnessed OHCA locations, covering 15.8% of the 653 public OHCAs from 2008 to 2016. The optimized locations provided significantly higher coverage (24.2%;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.