Evidence map›Paper›PMID 32814258›Full record

ArticleNeurobiology of aging2020

Changes in the intracellular microenvironment in the aging human brain.

Dinesh K Deelchand, J Riley McCarten, Laura S Hemmy, Edward J Auerbach, Lynn E Eberly, Małgorzata Marjańska

Abstract read
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Age dependency of neurometabolite TMagnetic resonance in medicine · 2025
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  8. Metabolite TMagnetic resonance in medicine · 2025
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  11. Metabolite TNMR in biomedicine · 2024
    Article
  12. Metabolite TbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dinesh K DeelchandCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. Electronic address: deelc001@umn.edu.
J Riley McCartenGeriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, Minneapolis, MN, USA; Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Laura S HemmyGeriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Edward J AuerbachCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Lynn E EberlyDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Małgorzata MarjańskaCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Mehmet Akcakaya · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Probing the Intracellular Environment in Normal Aging Using Magnetic ResonanceR21AG045606 · NIA · UNIVERSITY OF MINNESOTA · PI MARJANSKA, MALGORZATA · 2015 to 2016
$418k
NIA NIH HHS R21 AG045606NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

Normal brain aging is associated with changes occurring at all levels. This study investigates age-related differences in the brain intracellular microenvironment by comparing the apparent diffusion coefficients (ADC) and apparent transverse relaxation time constants (T

Indexed as

Brain ChemistryAdolescentAdultAgedAged, 80 and overAgingAspartic AcidBrainCellular MicroenvironmentCholineCreatineFemaleGlutamic AcidHumansInositolMagnetic Resonance SpectroscopyAspartic AcidCholineCreatineGlutamic AcidInositolADCDiffusionMagnetic resonance spectroscopyT(2)Young

Identifiers

PMID32814258
PMCPMC7609490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.