ArticleGastroenterology2021
Transcription and DNA Methylation Patterns of Blood-Derived CD8
Open access · bronzeAbstract read
In one paragraph
Article in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Reshaping study design for faster extrapolation-based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN-NASPGHAN position paper.Journal of pediatric gastroenterology and nutrition · 2026Pooled it
- Lymphocyte subsets for predicting inflammatory bowel disease progression and treatment response: a systematic review.Frontiers in immunology · 2024Pooled it
- Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2023Pooled it
- Defining PI3K Signaling as a Key Regulator of Molecular Heterogeneity and Inflammation in Glomerular Lupus Nephritis.Immune network · 2026Article
- Epigenetic Landscapes in Ulcerative Colitis: From Mechanistic Insights to Clinical Translation.ACS omega · 2025Review
- Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.Nature communications · 2025Article
- Article
- The Role of Chronic Inflammation in Pediatric Cancer.Cancers · 2025Review
- Peripheral Blood DNA Methylation Signatures and Response to Tofacitinib in Moderate-to-severe Ulcerative Colitis.Journal of Crohn's & colitis · 2024Article
- The Diagnosis of Intestinal Fibrosis in Crohn's Disease-Present and Future.International journal of molecular sciences · 2024Review
- Effects of DNA methylation and its application in inflammatory bowel disease (Review).International journal of molecular medicine · 2024Review
- Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease.Clinical epigenetics · 2024Article
- Hypomethylation and Overexpression of Th17-Associated Genes is a Hallmark of Intestinal CD4+ Lymphocytes in Crohn's Disease.Journal of Crohn's & colitis · 2023Article
- Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota.Cell & bioscience · 2023Review
- Omics and Multi-Omics in IBD: No Integration, No Breakthroughs.International journal of molecular sciences · 2023Review
- Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome.Journal of Crohn's & colitis · 2023Article
- Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2023Article
- New pattern of individualized management of chronic diseases: focusing on inflammatory bowel diseases and looking to the future.Frontiers in medicine · 2023Review
- Mucosal DNA methylome alteration in Crohn's disease: surgical and non-surgical groups.Frontiers in genetics · 2023Article
- Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on byReply.2021
Authors and funding
17 authors at 8 institutions in 1 country.
Marco GasparettoDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom.
Felicity PayneDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom.
Komal NayakDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Judith KraiczyDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Claire GlemasDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom.
Yosef Philip-McKenzieDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Alexander RossDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Rachel D EdgarEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
Daniel R ZerbinoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
Camilla SalvestriniDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom.
Franco TorrenteDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom.
Nicholas T VenthamAcademic Coloproctology, Western General Hospital, Edinburgh, Edinburgh, United Kingdom.
Rahul KallaMedical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Jack SatsangiTranslational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom.
Peter SarkiesMedical Research Council London Institute of Medical Sciences, United Kingdom; Institute of Clinical Sciences, Imperial College London, United Kingdom.
Robert HeuschkelDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom. Electronic address: robert.heuschkel@addenbrookes.nhs.uk.
Matthias ZilbauerDepartment of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke's, Cambridge, United Kingdom; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom. Electronic address: mz304@cam.ac.uk.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBEuropean Bioinformatics Institute · GBWellcome/MRC Cambridge Stem Cell Institute · GBCentre for Inflammation Research · GBNIHR Imperial Biomedical Research Centre · GBUniversity of Oxford · GBWestern General Hospital · GB
Funding
Chief Scientist Office ETM/395Medical Research Council MC_PC_12009Medical Research Council MC_PC_17230Wellcome Trust
Abstract
BACKGROUND &
aimsGene expression patterns of CD8
methodsWe obtained peripheral blood samples from 112 children with a new diagnosis of IBD (71 with Crohn's disease and 41 with ulcerative colitis) and 19 children without IBD (controls) and recorded medical information on disease activity and outcomes. CD8
resultsPreviously reported CD8
conclusionsWe were unable to validate previously reported findings of an association between CD8
Indexed as
AdolescentAdultAge FactorsCase-Control StudiesCD8-Positive T-LymphocytesChildChild, PreschoolDNA MethylationFemaleHumansInflammatory Bowel DiseasesMalePredictive Value of TestsPrognosisTranscription, GeneticYoung AdultBiomarkerEpigeneticPrognosisValidation
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.