ArticleJournal of theoretical biology2020
Rapid, large-scale, and effective detection of COVID-19 via non-adaptive testing.
Article in Journal of theoretical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- High prevalence group testing in epidemiology with geometrically inspired algorithms.Scientific reports · 2023Article
- Effective matrix designs for COVID-19 group testing.BMC bioinformatics · 2023Review
- Statistical modeling and evaluation of the impact of multiplicity classification thresholds on the COVID-19 pool testing accuracy.PloS one · 2023Article
- Constructions and Comparisons of Pooling Matrices for Pooled Testing of COVID-19.IEEE transactions on network science and engineering · 2022Article
- SARS-CoV-2 Diagnostics Based on Nucleic Acids Amplification: From Fundamental Concepts to Applications and Beyond.Frontiers in cellular and infection microbiology · 2022Review
- Pooled Testing Strategies for SARS-CoV-2 diagnosis: A comprehensive review.Diagnostic microbiology and infectious disease · 2021Review
- Pooling Nasopharyngeal Swab Specimens to Improve Testing Capacity for SARS-CoV-2 by Real-Time RT-PCR.Biological procedures online · 2021Article
- Efficient and effective single-step screening of individual samples for SARS-CoV-2 RNA using multi-dimensional pooling and Bayesian inference.Journal of the Royal Society, Interface · 2021Article
- Article
- Considerations for Pooled Testing of Employees for SARS-CoV-2.Journal of occupational and environmental medicine · 2021Article
- A Compressed Sensing Approach to Pooled RT-PCR Testing for COVID-19 Detection.IEEE open journal of signal processing · 2021Article
- Validation of SARS CoV-2 detection by real-time PCR in matched pooled and deconvoluted clinical samples before and after nucleic acid extraction: a study in tertiary care hospital of North India.Diagnostic microbiology and infectious disease · 2021Article
- Optimizing COVID-19 surveillance in long-term care facilities: a modelling study.BMC medicine · 2020Article
- Rapid, large-scale, and effective detection of COVID-19 via non-adaptive testing.Journal of theoretical biology · 2020Article
- Effectiveness of Sample Pooling Strategies for SARS-CoV-2 Mass Screening by RT-PCR: A Scoping Review.Journal of laboratory physicians · 2020Article
- Considerations for Group Testing: A Practical Approach for the Clinical Laboratory.The Clinical biochemist. Reviews · 2020Review
- Optimizing the diagnostic capacity for COVID-19 PCR testing for low resource and high demand settings: The development of information-dependent pooling protocol.Journal of global health · 2020Article
- Evaluation of pool-based testing approaches to enable population-wide screening for COVID-19.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pooling of samples can increase lab capacity when using Polymerase chain reaction (PCR) to detect diseases such as COVID-19. However, pool testing is typically performed via an adaptive testing strategy which requires a feedback loop in the lab and at least two PCR runs to confirm positive results. This can cost precious time. We discuss a non-adaptive testing method where each sample is distributed in a prescribed manner over several pools, and which yields reliable results after one round of testing. More precisely, assuming knowledge about the overall incidence rate, we calculate explicit error bounds on the number of false positives which scale favourably with pool size and sample multiplicity. This allows for hugely streamlined PCR testing and cuts in detection times for a large-scale testing scenario. A viable consequence of this method could be real-time screening of entire communities, frontline healthcare workers and international flight passengers, for example, using the PCR machines currently in operation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.