ArticleCell reports2020
Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Biochemical principles of SMAD signaling across the animal kingdom.The Biochemical journal · 2026Review
- EpicTope: predicting and validating non-disruptive epitope tagging sites.Development (Cambridge, England) · 2026Article
- Positional BMP signaling orchestrates villus length in the small intestine.Nature communications · 2025Article
- Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian.Science advances · 2025Article
- Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.Development (Cambridge, England) · 2025Article
- Quantitative Staging of Mid-blastula Zebrafish Embryos by Nuclei Counting.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.Development genes and evolution · 2024Review
- Context-dependent TGFβ family signalling in cell fate regulation.Nature reviews. Molecular cell biology · 2023Review
- Nodal signaling establishes a competency window for stochastic cell fate switching.Developmental cell · 2022Article
- Bmp4 Synexpression Gene,International journal of molecular sciences · 2022Article
- Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila.Biology open · 2022Article
- Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling.PLoS computational biology · 2021Article
- Diversity and robustness of bone morphogenetic protein pattern formation.Development (Cambridge, England) · 2021Review
- BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning.Frontiers in cell and developmental biology · 2021Review
- The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning.PLoS biology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A fundamental question in developmental biology is how morphogens, such as bone morphogenetic protein (BMP), form precise signaling gradients to impart positional and functional identity to the cells of the early embryo. We combine rigorous mutant analyses with quantitative immunofluorescence to determine that the proteases Bmp1a and Tolloid spatially restrict the BMP antagonist Chordin in dorsoventral (DV) axial patterning of the early zebrafish gastrula. We show that maternally deposited Bmp1a plays an unexpected and non-redundant role in establishing the BMP signaling gradient, while the Bmp1a/Tolloid antagonist Sizzled is surprisingly dispensable. Combining computational modeling and in vivo analyses with an immobile Chordin construct, we demonstrate that long-range Chordin diffusion is not necessary for BMP gradient formation and DV patterning. Our data do not support a counter-gradient of Chordin and instead favor a Chordin sink, established by Bmp1a and Tolloid, as the primary mechanism that drives BMP gradient formation.
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