ArticleActa anaesthesiologica Scandinavica2021
Chronic post-operative opioid use after open cardiac surgery: A Danish population-based cohort study.
Article in Acta anaesthesiologica Scandinavica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Superficial parasternal intercostal plane block with ropivacaine versus placebo for opioid exposure after cardiac surgery (EPOCH CardioLink-10): a multicentre, double-blind, randomised trial.Lancet regional health. Americas · 2026Article
- Pain Management in Minimally Invasive Cardiac Surgery: A Review of Current Clinical Evidence.Pain and therapy · 2025Review
- Predictors of new persistent opioid use after surgery in adults.Anesthesiology and perioperative science · 2025Article
- Hospital and long-term opioid use according to analgosedation with fentanyl vs. morphine: Findings from the ANALGESIC trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Measuring analgesia in ICU: no pain, no gain?Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Clinical Update on Patient-Controlled Analgesia for Acute Postoperative Pain.Pharmacy (Basel, Switzerland) · 2022Review
- Article
- Chronic post-operative opioid use after open cardiac surgery: A Danish population-based cohort study.Acta anaesthesiologica Scandinavica · 2021Article
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6 authors.
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Abstract
backgroundKnowledge of chronic opioid use after cardiac surgery is sparse. We therefore aimed to describe the proportion of new chronic post-operative opioid use after open cardiac surgery.
methodsWe used prospectively registered data from a national prescription registry and a clinical registry of 29 815 first-time cardiac surgeries from three Danish university hospitals. Data collection spanned from 2003 to 2016. The main outcome was chronic post-operative opioid use, defined as at least one opioid dispensing in the fourth post-operative quarter. Data were assessed for patient-level predictors of chronic post-operative opioid use, including pre-operative opioid use, opioid use at discharge, comorbidities, and procedural related variables.
resultsThe overall proportion of post-operative opioid use was 10.6% (95% CI: 10.2-10.9). The proportion of new chronic post-operative opioid use was 5.7% (95% CI: 5.5-6.0) among pre-operative opioid naïve patients. The corresponding proportions among patients, who pre-operatively used low or high dose opioid (1-500 mg or > 500 mg cumulative morphine equivalent opioid), were 68.3% (95% CI: 66.1-70.4) and 76.3% (95% CI: 74.0-78.5) respectively. Risk factors associated with new chronic post-operative opioid use included: female gender, underweight and obesity, pre-operative comorbidities, acute surgery, ICU-time > 1 day, and post-operative complications. Strongest predictor of chronic post-operative opioid use was post-discharge use of opioid within one month after surgery (odds ratio 3.3, 95% CI: 2.8-4.0).
conclusionNew chronic post-operative opioid use after open cardiac surgery is common. Focus on post-discharge opioid use may help clinicians to reduce rates of new chronic opioid users.
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