ArticleJournal of sport and health science2021
Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7.
Article in Journal of sport and health science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Ischemia during rest intervals between sets prevents decreases in fatigue during the explosive squat exercise: a randomized, crossover study.Scientific reports · 2022Trial
- Acute effects of BFR intra-conditioning on torque and muscle activity of the rectus femoris muscle during isokinetic knee extensions.Scientific reports · 2025Article
- The Role of miRNAs and Extracellular Vesicles in Adaptation After Resistance Exercise: A Review.Current issues in molecular biology · 2025Review
- Article
- Acute Impact of Different Reperfusion Duration Following Blood Flow Restriction on Bar Velocity during the Bench Press Exercise.Journal of human kinetics · 2025Article
- Effects of different ischemic pressures on bar velocity during the bench press exercise: A randomized crossover trial.Biology of sport · 2024Article
- Effects of High-Load Bench Press Training with Different Blood Flow Restriction Pressurization Strategies on the Degree of Muscle Activation in the Upper Limbs of Bodybuilders.Sensors (Basel, Switzerland) · 2024Article
- Enhancing lower limb and core muscle activation with blood flow restriction training: a randomized crossover study on high-intensity squat exercises.Frontiers in physiology · 2024Article
- Application of blood flow restriction in hypoxic environment augments muscle deoxygenation without compromising repeated sprint exercise performance.Experimental physiology · 2023Article
- Acute Effects of Ischemic Intra-Conditioning on 30 m Sprint Performance.International journal of environmental research and public health · 2022Article
- Effect of Low-Intensity Aerobic Training Combined with Blood Flow Restriction on Body Composition, Physical Fitness, and Vascular Responses in Recreational Runners.Healthcare (Basel, Switzerland) · 2022Article
- Resistance Training with Blood Flow Restriction and Ocular Health: A Brief Review.Journal of clinical medicine · 2022Review
- Long-term high loading intensity of aerobic exercise improves skeletal muscle performanceFrontiers in microbiology · 2022Article
- [Activation of mir-30a-wnt/β-catenin signaling pathway upregulates cathepsin K expression to promote cementogenic differentiation of periodontal ligament stem cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Blood flow restriction during the resting periods of high-intensity resistance training does not alter performance but decreases MIR-1 and MIR-133A levels in human skeletal muscle.Sports medicine and health science · 2021Article
- Acute Effects of Different Blood Flow Restriction Protocols on Bar Velocity During the Squat Exercise.Frontiers in physiology · 2021Article
- Tumor Cell-Derived Exosomal miR-770 Inhibits M2 Macrophage PolarizationFrontiers in cell and developmental biology · 2021Article
- The roles of microRNA in redox metabolism and exercise-mediated adaptation.Journal of sport and health science · 2020Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroudBlood flow restriction (BFR) with low-intensity resistance training has been shown to result in hypertrophy of skeletal muscle. In this study, we tested the hypothesis that BFR during the rest periods between acute, high-intensity resistance exercise sessions (70% of 1 repetition maximum, 7 sets with 10 repetitions) enhances the effects of the resistance training.
methodsA total of 7 healthy young men performed squats, and between sets BFR was carried out on one leg while the other leg served as a control. Because BFR was applied during rest periods, even severe occlusion pressure (approximately 230 mmHg), which almost completely blocked blood flow, was well-tolerated by the participants. Five muscle-specific microRNAs were measured from the biopsy samples, which were taken 2 h after the acute training.
resultsDoppler data showed that the pattern of blood flow recovery changed significantly between the first and last BFR. microRNA-206 levels significantly decreased in the BFR leg compared to the control. The mRNA levels of RAC-β serine/threonine-protein kinase v22, nuclear respiratory factor 1, vascular endothelial growth factor, lupus Ku autoantigen protein p70 genes (p < 0.05), and paired box 7 (p < 0.01) increased in the BFR leg. The protein levels of paired box 7, nuclear respiratory factor 1, and peroxisome proliferator-activated receptor γ coactivator 1α did not differ between the BFR leg and the control leg.
conclusionBFR, during the rest periods of high-load resistance training, could lead to mRNA elevation of those proteins that regulate angiogenesis, mitochondrial biogenesis, and muscle hypertrophy and repair. However, BFR also can cause DNA damage, judging from the increase in mRNA levels of lupus Ku autoantigen protein p70.
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