ArticleMolecular plant pathology2020
Functional variation in phyllogen, a phyllody-inducing phytoplasma effector family, attributable to a single amino acid polymorphism.
Article in Molecular plant pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- The pathogenic effector PHYL1The Plant journal : for cell and molecular biology · 2026Article
- Potato purple top phytoplasma infection induces autophagy-associated lipid dynamics that support pathogen proliferation.Plant physiology · 2026Article
- Putative Effector Genes Reveal Hidden Genetic Diversity Beyond Conventional Typing Markers in Flavescence Dorée Phytoplasmas.Pathogens (Basel, Switzerland) · 2026Article
- The phytoplasma effector, phyllogen, structurally mimics host plant MADS transcription factors.The Journal of biological chemistry · 2026Article
- Extended phenotype of phytoplasmas in eukaryotic systems: mechanisms and ecological implications.Frontiers in plant science · 2026Review
- Effector innovation in genome-reduced phytoplasmas and other host-dependent mollicutes.PLoS genetics · 2025Article
- A witches' broom phytoplasma effector induces stunting by stabilizing a bHLH transcription factor in Ziziphus jujuba plants.The New phytologist · 2025Article
- Sequencing and comparative analyses of 'Microbial genomics · 2025Article
- Phytoplasma: A plant pathogen that cannot be ignored in agricultural production-Research progress and outlook.Molecular plant pathology · 2024Review
- Target degradation specificity of phytoplasma effector phyllogen is regulated by the recruitment of host proteasome shuttle protein.Molecular plant pathology · 2024Article
- PhyEffector, the First Algorithm That Identifies Classical and Non-Classical Effectors in Phytoplasmas.Biomimetics (Basel, Switzerland) · 2023Article
- Detection, Identification and Molecular Characterization of the 16SrII-V Subgroup Phytoplasma Strain Associated withPlants (Basel, Switzerland) · 2023Article
- Random mutagenesis-based screening of the interface of phyllogen, a bacterial phyllody-inducing effector, for interaction with plant MADS-box proteins.Frontiers in plant science · 2023Article
- Potential mobile units drive the horizontal transfer of phytoplasma effectorFrontiers in genetics · 2023Article
- A phytoplasma effector acts as a ubiquitin-like mediator between floral MADS-box proteins and proteasome shuttle proteins.The Plant cell · 2022Article
- Phytoplasma effector Zaofeng6 induces shoot proliferation by decreasing the expression of ZjTCP7 in Ziziphus jujuba.Horticulture research · 2022Article
- Studying the Function of Phytoplasma Effector Proteins Using a Chemical-Inducible Expression System in Transgenic Plants.International journal of molecular sciences · 2021Article
- Article
- Accelerating Complete Phytoplasma Genome Assembly by Immunoprecipitation-Based Enrichment and MinION-Based DNA Sequencing for Comparative Analyses.Frontiers in microbiology · 2021Article
- Comparison of Current Methods for Signal Peptide Prediction in Phytoplasmas.Frontiers in microbiology · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flower malformation represented by phyllody is a common symptom of phytoplasma infection induced by a novel family of phytoplasma effectors called phyllogens. Despite the accumulation of functional and structural phyllogen information, the molecular mechanisms of phyllody have not yet been integrated with their evolutionary aspects due to the limited data on their homologs across diverse phytoplasma lineages. Here, we developed a novel universal PCR-based approach to identify 25 phytoplasma phyllogens related to nine "Candidatus Phytoplasma" species, including four species whose phyllogens have not yet been identified. Phylogenetic analyses showed that the phyllogen family consists of four groups (phyl-A, -B, -C, and -D) and that the evolutionary relationships of phyllogens were significantly distinct from those of phytoplasmas, suggesting that phyllogens were transferred horizontally among phytoplasma strains and species. Although phyllogens belonging to the phyl-A, -C, and -D groups induced phyllody, the phyl-B group lacked the ability to induce phyllody. Comparative functional analyses of phyllogens revealed that a single amino acid polymorphism in phyl-B group phyllogens prevented interactions between phyllogens and A- and E-class MADS domain transcription factors (MTFs), resulting in the inability to degrade several MTFs and induce phyllody. Our finding of natural variation in the function of phytoplasma effectors provides new insights into molecular mechanisms underlying the aetiology of phytoplasma diseases.
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