Evidence map›Paper›PMID 32813290›Full record

Trial reportHuman brain mapping2020

Working memory training restores aberrant brain activity in adult attention-deficit hyperactivity disorder.

Juha Salmi, Anna Soveri, Viljami Salmela, Kimmo Alho, Sami Leppämäki, Pekka Tani, Anniina Koski, Susanne M Jaeggi, Matti Laine

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Juha SalmiDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.ORCID 0000-0001-5623-6598
Anna SoveriDepartment of Clinical Medicine, University of Turku, Turku, Finland.
Viljami SalmelaDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Kimmo AlhoDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Sami LeppämäkiDepartment of Psychiatry, Helsinki University Hospital, Helsinki, Finland.
Pekka TaniDepartment of Psychiatry, Helsinki University Hospital, Helsinki, Finland.
Anniina KoskiDepartment of Psychiatry, Helsinki University Hospital, Helsinki, Finland.
Susanne M JaeggiSchool of Education, University of California Irvine, Irvine, California, USA.
Matti LaineDepartment of Psychology, Åbo Akademi University, Turku, Finland.
Helsinki University Hospital · FIUniversity of Helsinki · FIUniversity of Turku · FIÅbo Akademi University · FIUniversity of California, Irvine · US

Funding

Åbo Akademi University EndowmentAcademy of Finland #260054Academy of Finland #260276Academy of Finland #297848Academy of Finland #323251Academy of Finland #325981Academy of Finland #328954Stiftelsen för Åbo Akademi BrainTrain project
6 · The paper itself

Abstract

The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit hyperactivity disorder (ADHD). At baseline, we assessed the aberrant functional brain activity in the n-back WM task by comparing 44 adults with ADHD with 18 healthy controls using fMRI. Participants with ADHD were then randomized to train on an adaptive dual n-back task or an active control task. We tested whether WM training elicits redistribution of brain activity as observed in healthy controls, and whether it might further restore aberrant activity related to ADHD. As expected, activity in areas of the default-mode (DMN), salience (SN), sensory-motor (SMN), frontoparietal (FPN), and subcortical (SCN) networks was decreased in participants with ADHD at pretest as compared with healthy controls, especially when the cognitive load was high. WM training modulated widespread FPN and SN areas, restoring some of the aberrant activity. Training effects were mainly observed as decreased brain activity during the trained task and increased activity during the untrained task, suggesting different neural mechanisms for trained and transfer tasks.

Indexed as

Cognitive RemediationAdultAttention Deficit Disorder with HyperactivityCerebellumCerebral CortexDefault Mode NetworkExecutive FunctionHumansMagnetic Resonance ImagingMaleMemory, Short-TermNerve NetOutcome Assessment, Health CarePsychomotor PerformanceYoung AdultADHDbrain imagingcognitive trainingworking memory

Identifiers

PMID32813290
PMCPMC7643386
OpenAlexW3073856490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.