Evidence map›Paper›PMID 32813229›Full record

ReviewAmerican journal of clinical dermatology2020

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review.

Roberto Maglie, Giovanni Genovese, Farzan Solimani, Alba Guglielmo, Alessandro Pileri, Francesca Portelli, Michael Hertl, Angelo Valerio Marzano, Emiliano Antiga

Open access · hybridAbstract readReview
In one paragraph

Review in American journal of clinical dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Roberto MaglieDepartment of Health Sciences, Section of Dermatology, University of Florence, Viale Michelangiolo 41, 50125, Florence, Italy. robertomaglie.med@libero.it.ORCID http://orcid.org/0000-0002-5106-4042
Giovanni GenoveseDepartment of Physiopathology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Farzan SolimaniDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Alba GuglielmoDermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Alessandro PileriDermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Francesca PortelliDepartment of Health Sciences, Division of Pathological Anatomy, University of Florence, Florence, Italy.
Michael HertlDepartment of Dermatology and Allergology, Philipps-University, Marburg, Germany.
Angelo Valerio MarzanoDermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Emiliano AntigaDepartment of Health Sciences, Section of Dermatology, University of Florence, Viale Michelangiolo 41, 50125, Florence, Italy.
University of Florence · ITUniversity of Bologna · ITCharité - Universitätsmedizin Berlin · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITPhilipps University of Marburg · DEUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological malignancies, run a benign clinical course but portend a significant negative impairment on a patient's quality of life. In rare cases, the skin eruption reflects immunological alterations associated with an unfavourable prognosis of the associated haematological disorder. Therapeutic management of immune-mediated skin diseases in patients with haematological malignancies is often challenging. Systemic corticosteroids and immunosuppressive drugs are considered frontline therapies but may considerably augment the risk of serious infections. Indeed, developing a specific targeted therapeutic approach is of crucial importance for this particularly fragile patient population. This review provides an up-to-date overview on the immune-mediated skin diseases most frequently encountered by patients with onco-haematological disorders, discussing new pathogenic advances and therapeutic options on the horizon.

Indexed as

Hematologic NeoplasmsHumansImmunosuppressive AgentsParaneoplastic SyndromesPrognosisQuality of LifeSeverity of Illness IndexSkinSkin DiseasesTreatment OutcomeImmunosuppressive Agents

Identifiers

PMID32813229
PMCPMC7679319
OpenAlexW3056715291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.