ArticleEnvironmental geochemistry and health2021
Blood lead and cadmium levels in occupationally exposed workers and their effect on markers of DNA damage and repair.
Article in Environmental geochemistry and health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The waterpipe smoking and human health: a systematic review and meta-analysis of 191 observational studies.Systematic reviews · 2025Pooled it
- Impact of OGG1 and PARP1 Variants on Lead and Cadmium Induced DNA Damage in Metal Handicraft Workers of Jodhpur.Biological trace element research · 2026Article
- Article
- Lead and cadmium levels in blood among painters and battery workers: A case control study.Bioinformation · 2026Article
- Tattoo Ink Exposure and Its Potential Link with Lymphoma and Skin Cancer: A Narrative Review of New Evidence.Cardiovascular & hematological disorders drug targets · 2026Review
- Biomonitoring of heavy metal exposure and determinants of occupational risk in welders in Arba Minch Ethiopia.Scientific reports · 2025Article
- Synthesis of thiophene derived fluorescent sensor for HgScientific reports · 2025Article
- Environmental Hazards and Glial Brain Tumors: Association or Causation?International journal of molecular sciences · 2025Review
- A Major Latex Protein-Encoding Gene fromInternational journal of molecular sciences · 2025Article
- Effects of Cadmium and Lead Co-exposure on Sleep Status in Rural Areas Northwestern China.Biological trace element research · 2025Article
- Synergistic mechanisms of humic acid and biomineralization in cadmium remediation using Lysinibacillus fusiformis.Environmental microbiology reports · 2024Article
- The Protective Role of Ozone Therapy in Kidney Disease: A Review.Life (Basel, Switzerland) · 2023Review
- Transcriptional Regulatory Network of Plant Cadmium Stress Response.International journal of molecular sciences · 2023Review
- Role of Ape1 in Impaired DNA Repair Capacity in Battery Recycling Plant Workers Exposed to Lead.International journal of environmental research and public health · 2022Article
- Genotoxic Effects of Lead and Their Impact on the Expression of DNA Repair Genes.International journal of environmental research and public health · 2022Review
- Metal Exposures, Noise Exposures, and Audiometry from E-Waste Workers in Agbogbloshie, Ghana.International journal of environmental research and public health · 2021Article
- Assessment of circulating miR-20b, miR-221, and miR-155 in occupationally lead-exposed workers of North-Western India.Environmental science and pollution research international · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Occupational exposure to heavy metals like lead and cadmium causes a wide range of biological effects and may elevate the risk of genetic damage. Heavy metal toxicity is now becoming a significant public health problem. There are many discrepancies in the results of the studies on the genotoxicity of heavy metals. Therefore, the study aimed to estimate lead, cadmium, and 8-OHdG levels (8-hydroxy-2-deoxyguanosine) and expression of DNA repair gene OGG1 (8-oxoguanine DNA glycosylase 1) in occupationally heavy metal exposed workers. The study comprised 100 workers, occupationally exposed to lead and cadmium from different factories and 100 controls without history of metal exposure. The lead and cadmium mean ± SD were 5.69 ± 12.07 µg/dL and 3.44 ± 1.33 µg/L in the cases and 1.27 ± 1.10 µg/dL and 1.07 ± 0.67 µg/L in the controls. The 8-OHdG concentration was significantly higher in the cases than the controls. Cadmium showed a significant positive correlation with 8-OHdG in the cases. The expression of OGG1 was significantly down-regulated in the cases compared to the controls. Lead levels did not show any significant correlation with OGG1, whereas cadmium level had a significant positive correlation with OGG1 in the cases. To conclude, the exposure to heavy metals is associated with increased oxidative DNA damage and impaired expression of the DNA repair gene, OGG1.
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