Evidence map›Paper›PMID 32813120›Full record

ArticleBreast cancer research and treatment2020

Early stage breast cancer treatment and outcome of older patients treated in an oncogeriatric care and a standard care setting: an international comparison.

Anna Z de Boer, Willemien van de Water, Esther Bastiaannet, Nienke A de Glas, Mandy Kiderlen, Johanneke E A Portielje, Martine Extermann

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Survivorship Issues in Older Adults with Breast Cancer.Current breast cancer reports · 2025
    Article
  3. Article
  4. Article
  5. Research into ageing and frailty.Future healthcare journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna Z de BoerDepartment of Surgery, Leiden University Medical Center, Location J10-71, Postzone K6-R, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. a.z.de_boer@lumc.nl.ORCID http://orcid.org/0000-0002-4413-5308
Willemien van de WaterDepartment of Surgery, Leiden University Medical Center, Location J10-71, Postzone K6-R, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
Esther BastiaannetDepartment of Surgery, Leiden University Medical Center, Location J10-71, Postzone K6-R, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
Nienke A de GlasDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Mandy KiderlenDepartment of Radiotherapy, Erasmus Medical Center, Rotterdam, The Netherlands.
Johanneke E A PortieljeDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Martine ExtermannDepartment of Senior Adult Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Funding

KWF Kankerbestrijding 2007-3968
6 · The paper itself

Abstract

introductionSince older patients with breast cancer are underrepresented in clinical trials, an oncogeriatric approach is advocated to guide treatment decisions. However, the effect on outcomes is unclear. The aim of this study was to compare treatments and outcomes between patients treated in an oncogeriatric and a standard care setting.

methodsPatients aged ≥ 70 years with early stage breast cancer were included. The oncogeriatric cohort comprised unselected patients from the Moffitt Cancer Center, and the standard cohort patients from a Dutch population-based cohort. Cox models were used to characterize the influence of care setting on recurrence risk and overall mortality.

resultsOverall, 268 patients were included in the oncogeriatric and 1932 patients in the standard cohort. Patients in the oncogeriatric cohort were slightly younger, had more comorbidity, and received more adjuvant endocrine therapy and chemotherapy. Oncogeriatric care was associated with a lower risk of recurrence, which remained significant after adjustment for patient and tumour characteristics [hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.44-0.99]. Oncogeriatric care was also associated with a lower overall mortality, which also remained significant after adjustment for patient and tumour characteristics (HR 0.69, 95% CI 0.55-0.87).

conclusionsPatients treated in the oncogeriatric care setting had a lower risk of recurrence, which may be explained by more systemic treatment. Overall mortality was also lower, but other explanations besides care setting could not be ruled out as the cohorts had different patient profiles. Future studies need to clarify the impact of an oncogeriatric approach on outcomes.

Indexed as

Breast NeoplasmsAgedAged, 80 and overChemotherapy, AdjuvantCohort StudiesCombined Modality TherapyFemaleHumansNeoplasm Recurrence, LocalBreast cancerGeriatric assessmentGeriatric oncologyOncogeriatric careRecurrence risk

Identifiers

PMID32813120
PMCPMC7599178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.