ReviewApplied microbiology and biotechnology2020
Key elements and regulation strategies of NRPSs for biosynthesis of lipopeptides by Bacillus.
Review in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Genomic and functional characterization of Bacillus subtilis subsp. subtilis INPA R296 with emulsifying activity in cultivation with residual soybean oil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Genomic and transcriptomic analysis of yield enhancement mechanism of lipopeptide iturin W by tryptone supplementation.Microbiology spectrum · 2026Article
- Integrated genomic and metabolomic analysis reveals the biocontrol potential of endophytic Bacillus velezensis NS13 against Fusarium species in Lonicera macranthoides.BMC microbiology · 2026Article
- Bacterial Cyclic Lipopeptides as Triggers of Plant Immunity and Systemic Resistance Against Pathogens.Plants (Basel, Switzerland) · 2025Review
- Thermal and shear stress-induced phenotypic changes in Bacillus paralicheniformis TB197 in submerged liquid cultures.Applied microbiology and biotechnology · 2025Article
- The Characterization, Biological Activities, and Potential Applications of the Antimicrobial Peptides Derived from Bacillus spp.: A Comprehensive Review.Probiotics and antimicrobial proteins · 2025Review
- The Metabolic and Physiological Responses to Spaceflight of a Lipopeptide-Producing Bacillus subtilis.Microbial biotechnology · 2025Article
- Paenibacillus as a Biocontrol Agent for Fungal Phytopathogens: Is P. polymyxa the Only One Worth Attention?Microbial ecology · 2024Review
- An Integrated Pipeline and Overexpression of a Novel Efflux Transporter, YoeA, Significantly Increases Plipastatin Production inFoods (Basel, Switzerland) · 2024Article
- Strategies for improving fengycin production: a review.Microbial cell factories · 2024Review
- A review on surfactin: molecular regulation of biosynthesis.Archives of microbiology · 2023Review
- Review
- LC-MS and Transcriptome Analysis of Lipopeptide Biosynthesis byMolecules (Basel, Switzerland) · 2022Article
- Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced bySynthetic and systems biotechnology · 2022Article
- Transcriptome Analysis ofGenes · 2022Article
- Validation of reference genes for the normalization of RT-qPCR gene expression inIranian journal of microbiology · 2022Article
- Production of fengycin from D-xylose through the expression and metabolic regulation of the Dahms pathway.Applied microbiology and biotechnology · 2022Article
- Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides.Frontiers in chemistry · 2022Review
- Systemically engineeringFrontiers in bioengineering and biotechnology · 2022Article
- Microbial production of small peptide: pathway engineering and synthetic biology.Microbial biotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Lipopeptides are a group of second metabolites of Bacillus and have multiple activities such as inhibiting fungi, bacteria, viruses, and tumors, showing a great potential application in agricultural and biomedical fields. However, low production severely restrained their application in practice. Deeply understanding the key elements of lipopeptide synthesis and the regulatory strategies is essential to target the improvement of lipopeptide production. The synthetic pathways of different lipopeptides are different, but closely and mutually interfered. The loading of fatty acid chains and the extension of peptide chains are two key steps for the synthesis of different lipopeptides by Bacillus. The selection of fatty acid chains, the loading order of amino acids, and the recognition of the final cyclization site are the critical steps to determine the end products of different lipopeptides. In order to find the key elements for precisely directing the formation of different lipopeptides by Bacillus, the key structural elements and possible regulatory strategies that have been reported in the production of different lipopeptides, mainly surfactin, iturin, and fengycin by Bacillus, were summarized and compared. The possible ways to improve the production of different targeted lipopeptides were proposed. KEY POINTS: • The selectivity of fatty acids is determined by specific domains. • The COM domain and the PKS docking domain determine the order of amino acids. • The regulation patterns of different domains for lipopeptide synthesis are different. • The regulation of different lipopeptide products overlaps each other.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.