Evidence map›Paper›PMID 32813054›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Is it a new culprit? "TERT promoter mutation" in an aggressive pediatric pilocytic astrocytoma.

Jacintha Vikeneswary Francis, Bahattin Tanrıkulu, Ayca Ersen Danyeli, M Memet Özek

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jacintha Vikeneswary FrancisDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Acibadem University School of Medicine, Istanbul, Turkey.
Bahattin TanrıkuluDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Acibadem University School of Medicine, Istanbul, Turkey. bahattintanrikulu@gmail.com.ORCID 0000-0002-9096-8685
Ayca Ersen DanyeliDepartment of Pathology, Acibadem University School of Medicine, Istanbul, Turkey.
M Memet ÖzekDepartment of Neurosurgery, Division of Pediatric Neurosurgery, Acibadem University School of Medicine, Istanbul, Turkey.
Acıbadem University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in the genomic study have revolutionized the discovery of molecular biomarkers in glioma not only to aid in targeted therapy but also to prognosticate character of tumor and outcome of a patient.The usually benign nature of pilocytic astrocytoma (PA) can now be challenged with the discovery of genomic alterations that could promote more aggressive clinical behavior. CDKN2A deletion and ATRX gene inactivation or mutation have been the most common molecular alterations in worse prognosis.We will discuss a case of pilocytic astrocytoma showing the progressive recurrence with pilomyxoid features and the presence of TERT promoter mutation.

Indexed as

AstrocytomaBrain NeoplasmsGliomaTelomeraseChildHumansMutationNeoplasm Recurrence, LocalTelomeraseTERT protein, humanAggressiveMolecularPilocytic astrocytomaTERT promoter mutation

Identifiers

PMID32813054
OpenAlexW3052172464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.