Trial reportJournal of neurology2021
The emotional impact of the COVID-19 pandemic on individuals with progressive multiple sclerosis.
Trial report in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03679468 (Improving Cognition in People With Progressive Multiple Sclerosis), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Cognition in People With Progressive Multiple Sclerosis: A Multi-Arm, Randomized, Blinded, Sham-Controlled Trial of Cognitive Rehabilitation and Aerobic Exercise.
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The psychological impact of Covid-19 pandemic on people with Multiple Sclerosis: A meta-analysis.Multiple sclerosis and related disorders · 2022Pooled it
- Psychological impacts of COVID-19 pandemic on individuals living with multiple sclerosis: A rapid systematic review.Multiple sclerosis and related disorders · 2022Pooled it
- Financial Disruption and Psychological Underpinning During COVID-19: A Review and Research Agenda.Frontiers in psychology · 2022Pooled it
- A systematic review and meta-analysis of longitudinal cohort studies comparing mental health before versus during the COVID-19 pandemic in 2020.Journal of affective disorders · 2022Pooled it
- COVID-19 and disease-modifying therapies in patients with demyelinating diseases of the central nervous system: A systematic review.Multiple sclerosis and related disorders · 2021Pooled it
- The late onset of emotional distress in people with progressive multiple sclerosis during the Covid-19 pandemic: longitudinal findings from the CogEx study.Journal of neurology · 2022Trial
- Changes in Psychophysical Parameters in Seniors During the COVID-19 Pandemic-A Repeated Observational Study.Healthcare (Basel, Switzerland) · 2025Article
- Psychosocial Impact of the COVID-19 Pandemic Among Omanis with Multiple Sclerosis: Single Tertiary Center Experience.International journal of environmental research and public health · 2025Article
- Effects of COVID-19 Infection on Symptom Severity and Disability in Multiple Sclerosis.Neurology · 2025Article
- Evaluation of COVID-19 fear and sleep quality in individuals with epilepsy: a cross-sectional study.Frontiers in neurology · 2025Article
- The relationship between healthcare access and change in health-related quality-of-life among the general population of five countries during the COVID-19 pandemic.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Depression and anxiety in multiple sclerosis. Review of a fatal combination.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Outcomes of a Day Wellness Program for People With Multiple Sclerosis Before and During the COVID-19 Pandemic.International journal of MS care · 2024Article
- Article
- Era of COVID-19 in Multiple Sclerosis Care.Neurologic clinics · 2024Review
- Income loss and subsequent poor psychological well-being among the Chinese population during the early COVID-19 pandemic.International journal for equity in health · 2023Article
- Impact of the COVID-19 Pandemic on Mental Health among Patients with Chronic Ocular Conditions.Vision (Basel, Switzerland) · 2023Article
- Depression, Anxiety, and Suicidality in Individuals With Chronic Traumatic Brain Injury Before and During the COVID-19 Pandemic: A National Institute on Disability, Independent Living, and Rehabilitation Research Traumatic Brain Injury Model Systems Study.Archives of physical medicine and rehabilitation · 2023Article
- The Psychological Impact of COVID-19 Pandemic on Persons with Multiple Sclerosis in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2023Article
- Remote Observational Research for Multiple Sclerosis: A Natural Experiment.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 13 institutions in 6 countries.
Funding
Abstract
objectiveIndividuals with pre-existing chronic illness have shown increased anxiety and depression due to COVID-19. Here, we examine the impact of the COVID-19 pandemic on emotional symptomatology and quality of life in individuals with Progressive Multiple Sclerosis (PMS).
methodsData were obtained during a randomized clinical trial on rehabilitation taking place at 11 centers in North America and Europe. Participants included 131 individuals with PMS. Study procedures were interrupted in accordance with governmental restrictions as COVID-19 spread. During study closure, a COVID Impact Survey was administered via telephone or email to all participants, along with measures of depressive symptoms, anxiety symptoms, quality of life, and MS symptomatology that were previously administered pre-pandemic.
results4% of respondents reported COVID-19 infection. No significant changes were noted in anxiety, quality of life, or the impact of MS symptomatology on daily life from baseline to lockdown. While total HADS-depression scores increased significantly at follow-up, this did not translate into more participants scoring above the HADS threshold for clinically significant depression. No significant relationships were noted between disease duration, processing speed ability or EDSS, and changes in symptoms of depression or anxiety. Most participants reported the impact of the virus on their psychological well-being, with a little impact on financial well-being. The perceived impact of the pandemic on physical and psychological well-being was correlated with the impact of MS symptomatology on daily life, as well as changes in depression.
conclusionsOverall, little change was noted in symptoms of depression or anxiety or overall quality of life.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.