ArticleeLife2020
Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Mechanical memory of confinement pressure governs expansion size in epithelial monolayers.Life science alliance · 2026Article
- Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening.Toxicology · 2026Article
- Article
- Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening.bioRxiv : the preprint server for biology · 2025Article
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A new paradigm considering multicellular adhesion, repulsion and attraction represent diverse cellular tile patterns.PLoS computational biology · 2025Article
- Large-scale control over collective cell migration using light-activated epidermal growth factor receptors.Cell systems · 2025Article
- Quantifying cell cycle regulation by tissue crowding.Biophysical journal · 2025Article
- The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients.Frontiers in bioengineering and biotechnology · 2025Article
- Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission.PLoS computational biology · 2025Article
- A programmable, open-source robot that scratches cultured tissues to investigate cell migration, healing, and tissue sculpting.Cell reports methods · 2024Article
- SCRATCH: A programmable, open-hardware, benchtop robot that automatically scratches cultured tissues to investigate cell migration, healing, and tissue sculpting.bioRxiv : the preprint server for biology · 2024Article
- Cellular Energy Cycle Mediates an Advection-Like Forward Cell Flow to Support Collective Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Large-scale control over collective cell migration using light-controlled epidermal growth factor receptors.bioRxiv : the preprint server for biology · 2024Article
- Collective Cell Radial Ordered Migration in Spatial Confinement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mechanical control of cell proliferation patterns in growing epithelial monolayers.Biophysical journal · 2024Article
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.Soft matter · 2023Article
- Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.Bulletin of mathematical biology · 2023Article
- Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions.Developmental cell · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The coordination of cell proliferation and migration in growing tissues is crucial in development and regeneration but remains poorly understood. Here, we find that, while expanding with an edge speed independent of initial conditions, millimeter-scale epithelial monolayers exhibit internal patterns of proliferation and migration that depend not on the current but on the initial tissue size, indicating memory effects. Specifically, the core of large tissues becomes very dense, almost quiescent, and ceases cell-cycle progression. In contrast, initially-smaller tissues develop a local minimum of cell density and a tissue-spanning vortex. To explain vortex formation, we propose an active polar fluid model with a feedback between cell polarization and tissue flow. Taken together, our findings suggest that expanding epithelia decouple their internal and edge regions, which enables robust expansion dynamics despite the presence of size- and history-dependent patterns in the tissue interior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.