ArticleeLife2020
What is the true discharge rate and pattern of the striatal projection neurons in Parkinson's disease and Dystonia?
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses.PLoS computational biology · 2025Article
- Early synaptic dysfunction of striatal parvalbumin interneurons in a mouse model of Parkinson's disease.iScience · 2024Article
- Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients.Nature communications · 2024Article
- Why so slow? Models of parkinsonian bradykinesia.Nature reviews. Neuroscience · 2024Review
- Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation.NPJ Parkinson's disease · 2024Article
- In Vitro Pharmacological Modulation of PIEZO1 Channels in Frontal Cortex Neuronal Networks.Brain sciences · 2024Article
- The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.Network neuroscience (Cambridge, Mass.) · 2024Article
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
- The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression.Neuron · 2023Article
- Association between Severity of Freezing of Gait and Turning Characteristics in People with Parkinson's Disease.International journal of environmental research and public health · 2022Article
- Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dopamine depletion selectively disrupts interactions between striatal neuron subtypes and LFP oscillations.Cell reports · 2022Article
- Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology.Frontiers in network physiology · 2022Review
- The Origin of Abnormal Beta Oscillations in the Parkinsonian Corticobasal Ganglia Circuits.Parkinson's disease · 2022Review
- Debunking an old theory.eLife · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine and striatal dysfunctions play a key role in the pathophysiology of Parkinson's disease (PD) and Dystonia, but our understanding of the changes in the discharge rate and pattern of striatal projection neurons (SPNs) remains limited. Here, we recorded and examined multi-unit signals from the striatum of PD and dystonic patients undergoing deep brain stimulation surgeries. Contrary to earlier human findings, we found no drastic changes in the spontaneous discharge of the well-isolated and stationary SPNs of the PD patients compared to the dystonic patients or to the normal levels of striatal activity reported in healthy animals. Moreover, cluster analysis using SPN discharge properties did not characterize two well-separated SPN subpopulations, indicating no SPN subpopulation-specific (D1 or D2 SPNs) discharge alterations in the pathological state. Our results imply that small to moderate changes in spontaneous SPN discharge related to PD and Dystonia are likely amplified by basal ganglia downstream structures.
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