Evidence map›Paper›PMID 32812650›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2020

Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia.

Alfred O Osoti, Stephanie T Page, Barbra A Richardson, Brandon L Guthrie, John Kinuthia, Stephen J Polyak, Carey Farquhar

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Alfred O OsotiDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Stephanie T PageDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, Diabetes Institute, University of Washington, Seattle, WA, USA.
Barbra A RichardsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Brandon L GuthrieDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
John KinuthiaDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
Stephen J PolyakDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Carey FarquharDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
University of Washington · USInstitute of Nutrition, Metabolism and Diabetes · CAUniversity of Nairobi · KE

Funding

Promoting Diversity, Equity, and Inclusivity in Research Training to Optimize HIV Prevention and TreatmentD43TW009580 · FIC · UNIVERSITY OF WASHINGTON · PI CAREY FARQUHAR, John Kinuthia · 2013 to 2026
$4.8M
Gestational diabetes mellitus, gestational hypertension and risk of metabolic syndromeK43TW010363 · FIC · UNIVERSITY OF NAIROBI · PI OSOTI, ALFRED ONYANGO · 2016 to 2020
$566k
FIC NIH HHS D43 TW009580FIC NIH HHS K43 TW010363NIDA NIH HHSNIH HHS D43 TW009580NIH HHS K43 TW010363NIMH NIH HHS
6 · The paper itself

Abstract

objectiveTo evaluate the association between metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hsCRP), a biomarker of chronic inflammation and an independent predictor for cardiovascular disease overall and in subgroups of women with/without pre-eclampsia and gestational hypertension (GHT).

methodsA prospective cohort study was conducted in Nairobi, Kenya. Women with pre-eclampsia or GHT and normotensive women within 12 weeks postpartum underwent physical, anthropometric, fasting lipid profile, plasma glucose, and hsCRP measurements at 6 months postpartum. A generalized linear regression model with Poisson distribution adjusted for body mass index and age was used to estimate the association between elevated hsCRP and MetS overall and stratified by pre-eclampsia or GHT.

resultsIn the 171 women included in the study, risk of elevated hsCRP (>3 mg/L) was greater among women with compared to those without MetS (adjusted relative risk [ARR] 1.70, 95% confidence interval [CI] 1.05-2.73, P=0.03) and was statistically significantly higher in the hypertensive (ARR 2.16 95% CI 1.01-4.62, P=0.04) but not in the normotensive (ARR 1.46, 95% CI 0.93-2.28) group.

conclusionIncreased risk of elevated hsCRP postpartum can guide longitudinal mechanistic and intervention studies to reduce postpartum cardiovascular morbidity in women with MetS, especially after pre-eclampsia or GHT.

Indexed as

AdultBiomarkersCardiovascular DiseasesCohort StudiesC-Reactive ProteinFemaleHumansHypertension, Pregnancy-InducedKenyaMetabolic SyndromePostpartum PeriodPre-EclampsiaPregnancyPregnancy ComplicationsProspective StudiesRisk FactorsBiomarkersC-Reactive ProteinCardiovascularGestationalHigh-sensitivity C-reactive proteinMetabolic syndromePostpartumPre-eclampsia

Identifiers

PMID32812650
PMCPMC7722223
OpenAlexW3068597066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.