Evidence map›Paper›PMID 32812643›Full record

ArticleThe Biochemical journal2020

Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus.

Annie Yap, Matthias Misslinger, Hubertus Haas

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in The Biochemical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Ambient Availability of Amino Acids, Proteins, and Iron Impacts Copper Resistance ofFrontiers in cellular and infection microbiology · 2022
    Article
  2. Article
  3. The Role of Zinc in Copper Homeostasis ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Annie YapInstitute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria.
Matthias MisslingerInstitute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria.
Hubertus HaasInstitute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria.
Innsbruck Medical University · AT

Funding

Austrian Science Fund FWF W 1253
6 · The paper itself

Abstract

Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.

Indexed as

Aspergillus fumigatusCopperFungal ProteinsGene Expression Regulation, FungalIronTranscription FactorsVirulenceCopperFungal ProteinsIronTranscription Factorscoppergene expression and regulationironmycology

Identifiers

PMID32812643
OpenAlexW3080410313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.