ArticleThe Journal of international medical research2020
The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular Mechanisms of Local Anesthetic Toxicity: From Ion Channel Dysregulation to Mitochondrial Dysfunction and Tissue-Specific Injury.International journal of molecular sciences · 2026Review
- Sudden neonatal death following circumcision associated with bupivacaine-induced Local Anesthetic Systemic Toxicity (LAST): a forensic case report.Forensic science, medicine, and pathology · 2026Article
- Local Anesthetic Toxicity in Epidural Analgesia for Elderly Patients: A Case Report.Case reports in anesthesiology · 2026Article
- Enantiomeric Excess Bupivacaine in a Lavender Oil NLC Tested in a Melanoma Model: Prolonged Release and Anticancer Effect.Molecular pharmaceutics · 2025Article
- Local anaesthetics risks perception: A web-based survey.Heliyon · 2024Article
- A Myriad of Symptoms After Spinal Anesthesia: A Case Report of Local Anesthetic Systemic Toxicity.Cureus · 2022Article
- Peripartum Management of Gitelman Syndrome for Vaginal Delivery: A Case Report and Review of Literature.Anesthesia, essays and researchesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBupivacaine is an amide local anesthetic with possible side effects that include an irregular heart rate. However, the mechanism of bupivacaine-induced cardiotoxicity has not been fully elucidated, thus we aimed to examine this mechanism.
methodsWe performed electrocardiogram recordings to detect action potential waveforms in Sprague Dawley rats after application of bupivacaine, while calcium (Ca
resultsIn the present study, after application of bupivacaine, abnormal action potential waveforms were detected in Sprague Dawley rats by electrocardiogram recordings, while decreased Ca
conclusionsThe present study identifies a possible role of the calreticulin-Ca
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Registered trials
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