ArticleMicrobial biotechnology2021
Geographic pattern of antibiotic resistance genes in the metagenomes of the giant panda.
Article in Microbial biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Prevalence, resistance profile, and molecular epidemiology of extended-spectrum β-lactamases producingOne health (Amsterdam, Netherlands) · 2026Article
- Seasonal diet shifts alter the gut microbiome and resistome of captive geriatric giant pandas (Ailuropoda melanoleuca).BMC microbiology · 2026Article
- Safeguarding a Flagship Species: Integrated Surveillance of Cross-Species Pathogen Transmission in Giant Panda Ecosystems.Ecology and evolution · 2026Review
- Intersite differences in gut microbiome are associated with habitat quality in a limestone forest-dwelling langur.BMC microbiology · 2026Article
- Intestinal microbiome gone native: gut microbiome shift and resistome diversity in first homecoming giant panda family.Frontiers in microbiology · 2026Article
- Dynamics of the gut microbiome and resistome in response to prophylactic antibiotic treatment in post-surgical giant pandas.Scientific reports · 2025Article
- Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.Communications biology · 2025Article
- Evolutionary and Ecological Drivers of Gut Microbiota in Wild Rodent Species from the Yucatán Peninsula.Microbial ecology · 2025Article
- Metagenome Analysis Reveals Changes in Gut Microbial Antibiotic Resistance Genes and Virulence Factors in Reintroduced Giant Pandas.Microorganisms · 2025Article
- Distribution of antibiotic resistance genes and their pathogen hosts in duck farm environments in south-east coastal China.Applied microbiology and biotechnology · 2024Review
- Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca).BMC veterinary research · 2024Article
- Molecular identification ofOpen veterinary journal · 2024Article
- The Potential of Co-Evolution and Interactions of Gut Bacteria-Phages in Bamboo-Eating Pandas: Insights from Dietary Preference-Based Metagenomic Analysis.Microorganisms · 2024Article
- Characterization of antibiotic resistance genes and mobile genetic elements in Escherichia coli isolated from captive black bears.Scientific reports · 2024Article
- Article
- Geographic and environmental impacts on gut microbiome in Himalayan langurs (Frontiers in microbiology · 2024Article
- The Impact of Bamboo Consumption on the Spread of Antibiotic Resistance Genes in Giant Pandas.Veterinary sciences · 2023Article
- Age-related alterations in metabolome and microbiome provide insights in dietary transition in giant pandas.mSystems · 2023Article
- Comparison of Fecal Antimicrobial Resistance Genes in Captive and Wild Asian Elephants.Antibiotics (Basel, Switzerland) · 2023Article
- Beyond bacteria: Reconstructing microorganism connections and deciphering the predicted mutualisms in mammalian gut metagenomes.Ecology and evolution · 2023Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rise in infections by antibiotic-resistant bacteria poses a serious public health problem worldwide. The gut microbiome of animals is a reservoir for antibiotic resistance genes (ARGs). However, the correlation between the gut microbiome of wild animals and ARGs remains controversial. Here, based on the metagenomes of giant pandas (including three wild populations from the Qinling, Qionglai and Xiaoxiangling Mountains, and two major captive populations from Yaan and Chengdu), we investigated the potential correlation between the constitution of the gut microbiome and the composition of ARGs across the different geographic locations and living environments. We found that the types of ARGs were correlated with gut microbiome composition. The NMDS cluster analysis using Jaccard distance of the ARGs composition of the gut microbiome of wild giant pandas displayed a difference based on geographic location. Captivity also had an effect on the differences in ARGs composition. Furthermore, we found that the Qinling population exhibited profound dissimilarities of both gut microbiome composition and ARGs (the highest proportion of Clostridium and vancomycin resistance genes) when compared to the other wild and captive populations studies, which was supported by previous giant panda whole-genome sequencing analysis. In this study, we provide an example of a potential consensus pattern regarding host population genetics, symbiotic gut microbiome and ARGs. We revealed that habitat isolation impacts the ARG structure in the gut microbiome of mammals. Therefore, the difference in ARG composition between giant panda populations will provide some basic information for their conservation and management, especially for captive populations.
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