ArticleThe Journal of comparative neurology2021
Retina-specific targeting of pericytes reveals structural diversity and enables control of capillary blood flow.
Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Region-specific pericyte Ca2+ transient dynamics and capillary hemodynamics during the sleep-wake cycle.Sleep · 2026Article
- A neurobiology perspective on the assembly of retinal vasculature from 2D to 3D.Current opinion in neurobiology · 2025Review
- Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation.bioRxiv : the preprint server for biology · 2025Article
- Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβJournal of neurochemistry · 2025Article
- Reciprocal Inhibitions of HRP and REC in a Coculture System.Archives of ophthalmology and optometry · 2025Article
- Imaging the Retinal Vascular Mural Cells In Vivo: Elucidating the Timeline of Their Loss in Diabetic Retinopathy.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Review
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.Development (Cambridge, England) · 2023Article
- Article
- Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography.Scientific reports · 2023Article
- Pericyte-derived cells participate in optic nerve scar formation.Frontiers in physiology · 2023Article
- Neurotransmitter phenotype and axonal projection patterns of VIP-expressing neurons in the inferior colliculus.Journal of chemical neuroanatomy · 2022Article
- Rapid 3D-STORM imaging of diverse molecular targets in tissue.Cell reports methods · 2022Article
- Review
- AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43.The Journal of comparative neurology · 2022Article
- Pericyte heterogeneity identified by 3D ultrastructural analysis of the microvessel wall.Frontiers in physiology · 2022Article
- Deficiency of Notch signaling in pericytes results in arteriovenous malformations.JCI insight · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pericytes are a unique class of mural cells essential for angiogenesis, maintenance of the vasculature and are key players in microvascular pathology. However, their diversity and specific roles are poorly understood, limiting our insight into vascular physiology and the ability to develop effective therapies. Here, in the mouse retina, a tractable model of the CNS, we evaluated distinct classes of mural cells along the vascular tree for both structural characterization and physiological manipulation of blood flow. To accomplish this, we first tested three inducible mural cell-specific mouse lines using a sensitive Ai14 reporter and tamoxifen application either by a systemic injection, or by local administration in the form of eye drops. The specificity and pattern of cre activation varied significantly across the three lines, under either the PDGFRβ or NG2 promoter (Pdgfrβ-CreRha, Pdgfrβ-CreCsln, and Cspg4-Cre). In particular, a mouse line with Cre under the NG2 promoter resulted in sparse TdTomato labeling of mural cells, allowing for an unambiguous characterization of anatomical features of individual sphincter cells and capillary pericytes. Furthermore, in one PDGFRβ line, we found that focal eye drop application of tamoxifen led to an exclusive Cre-activation in pericytes, without affecting arterial mural cells. We then used this approach to boost capillary blood flow by selective expression of Halorhodopsin, a highly precise hyperpolarizing optogenetic actuator. The ability to exclusively target capillary pericytes may prove a precise and potentially powerful tool to treat microcirculation deficits, a common pathology in numerous diseases.
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