Evidence map›Paper›PMID 32812215›Full record

Trial reportClinical and experimental immunology2020

Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens.

J C Burns, L E Hsieh, J Kumar, N Behnamfar, C Shimizu, N Sivilay, A H Tremoulet, A Franco

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Characterization of the T Cell Response toFrontiers in pediatrics · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

J C BurnsSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
L E HsiehSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1179-2229
J KumarSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
N BehnamfarSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
C ShimizuSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
N SivilaySchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
A H TremouletSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
A FrancoSchool of Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
University of California San Diego · US

Funding

How immunodominant Fc peptide epitopes expand natural regulatory T cells and downregulate inflammationR01AI143586 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FRANCO, ALESSANDRA I · 2019 to 2021
$1.3M
NIAID NIH HHS R01 AI143586
6 · The paper itself

Abstract

Kawasaki disease (KD) is an acute pediatric vasculitis of unknown etiology that can cause coronary artery aneurysms, and is the leading cause of acquired heart disease in children. We studied aspects of the innate and adaptive immune response in 17 acute KD children prior to treatment with intravenous immunoglobulin. Distinct patterns within the innate immune response correlated with specific clinical features. Proinflammatory myeloid dendritic cells (mDC) were abundant in four of 17 (23·5%) subjects who were older and manifested severe inflammation with clinical myocarditis and elevated hepatobiliary enzyme levels. Of the nine subjects with low levels of anti-inflammatory, tolerogenic mDC, six had enlarged cervical lymph nodes at diagnosis. In contrast, the adaptive immune repertoire varied greatly with no discernible patterns or associations with clinical features. Two subjects with aneurysms had numerous circulating CD8

Indexed as

Acute DiseaseAntigensChildChild, PreschoolDendritic CellsFemaleHumansImmunoglobulins, IntravenousInfantLymphocytesMaleMucocutaneous Lymph Node SyndromeAntigensImmunoglobulins, Intravenousacute pediatric vasculitisantigenic triggersimmune monitoring

Identifiers

PMID32812215
PMCPMC7670149
OpenAlexW3062604958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.