SynthesisWorld journal of surgery2020
Meta-Analysis and Meta-Regression of Risk Factors for Surgical Site Infections in Hepatic and Pancreatic Resection.
Synthesis in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05548764 (Prevention Bundles for Surgical Site Infections), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention Bundles for Surgical Site Infections (PREBUSSI): a Multi-center Observational Study.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Surgical site infection after open versus minimally invasive left pancreatectomy: a retrospective cohort study.Surgical endoscopy · 2026Article
- Novel Therapeutic Approaches and Alternatives to Antibiotic Therapy for Drug-Resistant Intra-Abdominal Infections.Antibiotics (Basel, Switzerland) · 2026Review
- Distribution of pathogenic bacteria and analysis of risk factors for surgical site infections after hepatobiliary surgery.BMC infectious diseases · 2026Article
- Microbiological Findings and Risk Profiles in Hepatobiliary and Pancreatic Surgery Associated Surgical Site Infections: A Retrospective Cohort Study.Pathogens (Basel, Switzerland) · 2025Article
- Piperacillin reaches high concentrations in bile and target tissues of the biliary system: an experimental study in pigs.Antimicrobial agents and chemotherapy · 2025Article
- Epidemiology and Management of Postoperative Infections in Hepatectomy and Pancreaticoduodenectomy.Journal of surgery and research · 2025Article
- Adaptation of antibiotics and antifungal strategy to preoperative biliary drainage to improve postoperative outcomes after pancreatic head resection.World journal of surgery · 2025Article
- Article
- Reduction of Postoperative Complications in Pancreatic Surgery by Standardizing Perioperative Management: An Observational Cohort Study.Visceral medicine · 2024Article
- Comparison of prognosis and postoperative morbidities between standard pancreaticoduodenectomy and the TRIANGLE technique for resectable pancreatic ductal adenocarcinoma.World journal of gastrointestinal surgery · 2024Article
- Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study.Antimicrobial resistance and infection control · 2023Article
- Comparison of Cefazolin and Ceftriaxone as Antimicrobial Prophylaxis in Pancreatoduodenectomy with Preoperative Drainage: Incidence of Surgical Site Infection and Susceptibility of Bacteria in Bile.World journal of surgery · 2023Article
- Diagnostic value of inflammatory indicators for surgical site infection in patients with breast cancer.Frontiers in cellular and infection microbiology · 2023Article
- The role of preoperative albumin and white blood cell count in surgical site infections following whipple surgery.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk factors for surgical site infection (SSI) after HPB surgery are poorly defined. This meta-analysis aimed to quantify the SSI rates and risk factors for SSI after pancreas and liver resection.
methodsThe PUBMED, MEDLINE and EMBASE databases were systematically searched using the PRISMA framework. The primary outcome measure was pooled SSI rates. The secondary outcome measure was risk factor profile determination for SSI.
resultsThe overall rate of SSI after pancreatic and liver resection was 25.1 and 10.4%, respectively (p < 0.001). 32% of pancreaticoduodenectomies developed SSI vs 23% after distal pancreatectomy (p < 0.001). The rate of incisional SSI in the pancreatic group was 9% and organ/space SSI 16.5%. Biliary resection during liver surgery was a risk factor for SSI (25.0 vs 15.7%, p = 0.002). After liver resection, the incisional SSI rate was 7.6% and the organ space SSI rate was 10.2%. Pancreas-specific SSI risk factors were pre-operative biliary drainage (p < 0.001), chemotherapy (p < 0.001) and radiotherapy (p = 0.007). Liver-specific SSI risk factors were smoking (p = 0.046), low albumin (p < 0.001) and significant blood loss (p < 0.001). The rate of organ/space SSI in patients with POPF was 47.7% and in patients without POPF 7.3% (p < 0.001). Organ/space SSI rate was 43% in patients with bile leak and 10% in those without (p < 0.001).
conclusionsThe risk factors for SSI following pancreatic and liver resections are distinct from each other, with higher SSI rates after pancreatic resection. Pancreaticoduodenectomy has increased risk of SSI compared to distal pancreatectomy. Similarly, biliary resections during liver surgery increase the rates of SSI.
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