Evidence map›Paper›PMID 32812075›Full record

ArticleSurgery today2021

Elemental diet therapy plays a significant role in preventing surgical recurrence of Crohn's disease in the era of biologics.

Masaru Shinozaki, Tadashi Yokoyama, Naoto Saigusa, Hajime Sato, Kentaro Yazawa, Giichiro Tsurita, Tomohiro Kurokawa, Keisuke Hata, Yasuhisa Yokoyama

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In one paragraph

Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Masaru ShinozakiDepartment of Surgery, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. mshino@ims.u-tokyo.ac.jp.
Tadashi YokoyamaYokoyama IBD Clinic, Nagoya, Japan.
Naoto SaigusaYokoyama Memorial Hospital, Nagoya, Japan.
Hajime SatoDepartment of Health Policy and Technology Assessment, National Institute of Public Health, Wako, Japan.
Kentaro YazawaDepartment of Surgery, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Giichiro TsuritaDepartment of Surgery, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Tomohiro KurokawaDepartment of Surgery, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Keisuke HataDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yasuhisa YokoyamaYokoyama Memorial Hospital, Nagoya, Japan.
The University of Tokyo · JPNational Institute of Public Health · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost patients with Crohn's disease (CD) experience surgical recurrence. In this era of novel therapies, we conducted this study to clarify which treatments effectively decrease the risk of surgical recurrence in patients with CD.

methodsThe subjects of this retrospective study were 37 patients with CD. We created cumulative surgery rate curves and performed univariate and multivariate analyses.

resultsUnivariate analysis revealed that patients who consumed an elemental diet (ED; ≥ 900 kcal/day), anti-tumor necrosis factor-alpha, and thiopurines had a significantly better prognosis than those who did not (p = 0.011, p = 0.025, and p = 0.0080, respectively). Multivariate analysis revealed that ED therapy and thiopurines were independent significant factors for controlling surgical recurrence (p = 0.046 and p = 0.032, respectively). Additional analyses showed that the most promising ED therapeutic dose was ≥ 1200 kcal/day, while an ED therapeutic dose of ≥ 900 kcal/day was acceptable.

conclusionsAlthough univariate analyses revealed that all three treatment strategies had significant effects on surgical recurrence in patients with CD, multivariate analysis revealed that only ED therapy was significantly associated with surgical recurrence rates. Thus, ED therapy plays an important role in the management of CD, even in the era of biological therapies.

Indexed as

Food, FormulatedSecondary PreventionAdultAgedAnalysis of VarianceCrohn DiseaseDigestive System Surgical ProceduresFemaleHumansMaleMiddle AgedPrognosisRecurrenceReoperationRetrospective StudiesRiskCrohn’s diseaseElemental diet therapySurgical recurrence

Identifiers

PMID32812075
OpenAlexW3068477746

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.