ArticleScientific reports2020
Implications of back-and-forth motion and powerful propulsion for spirochetal invasion.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Core-sheath coupling controls flagellar curvature and motility in Leptospira.Nature communications · 2026Article
- A periplasmic layer formed by an outer membrane lipoprotein governs the cell-envelope integrity and stiffness of Leptospira interrogans.Communications biology · 2026Article
- Measurement of the Cell-Body Rotation of Leptospira.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The role of morphological adaptability inmBio · 2025Article
- FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi.PLoS pathogens · 2025Article
- The bacterial flagellum as an object for optical trapping.Biophysical reviews · 2024Review
- Force Measurement of Bacterial Swimming Using Optical Tweezers.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Frontiers of microbial movement research.Biophysics and physicobiology · 2023Article
- Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Motility of the Zoonotic SpirocheteInternational journal of molecular sciences · 2022Review
- A geometric criterion for the optimal spreading of active polymers in porous media.Nature communications · 2021Article
- Pathogenesis insights from an ancient and ubiquitous spirochete.PLoS pathogens · 2021Review
- Disassembly of the apical junctional complex during the transmigration of Leptospira interrogans across polarized renal proximal tubule epithelial cells.Cellular microbiology · 2021Article
- Updated ACVIM consensus statement on leptospirosis in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spirochete Leptospira spp. can move in liquid and on a solid surface using two periplasmic flagella (PFs), and its motility is an essential virulence factor for the pathogenic species. Mammals are infected with the spirochete through the wounded dermis, which implies the importance of behaviors on the boundary with such viscoelastic milieu; however, the leptospiral pathogenicity involving motility remains unclear. We used a glass chamber containing a gel area adjoining the leptospiral suspension to resemble host dermis exposed to contaminated water and analyzed the motility of individual cells at the liquid-gel border. Insertion of one end of the cell body to the gel increased switching of the swimming direction. Moreover, the swimming force of Leptospira was also measured by trapping single cells using an optical tweezer. It was found that they can generate [Formula: see text] 17 pN of force, which is [Formula: see text] 30 times of the swimming force of Escherichia coli. The force-speed relationship suggested the load-dependent force enhancement and showed that the power (the work per unit time) for the propulsion is [Formula: see text] 3.1 × 10
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Registered trials
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