Evidence map›Paper›PMID 32811878›Full record

ArticleScientific reports2020

Stimulus-specific regulation of visual oddball differentiation in posterior parietal cortex.

Zhe Charles Zhou, Wei Angel Huang, Yiyi Yu, Ehsan Negahbani, Iain M Stitt, Morgan L Alexander, Jordan P Hamm, Hiroyuki K Kato, Flavio Fröhlich

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  6. The Central Thalamus: Gatekeeper or Processing Hub?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhe Charles ZhouDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA.
Wei Angel HuangDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA.
Yiyi YuDepartment of Biomedical Sciences, University of California at Santa Barbara, Los Angeles, CA, 90048, USA.
Ehsan NegahbaniDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA.
Iain M StittDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA.
Morgan L AlexanderDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA.
Jordan P HammNeuroscience Institute, Georgia State University, Atlanta, GA, 30302, USA.
Hiroyuki K KatoDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA.
Flavio FröhlichDepartment of Psychiatry, University of North Carolina at Chapel Hill, 116 Manning Drive, 6018A, Chapel Hill, NC, 27599, USA. flavio_frohlich@med.unc.edu.
University of North Carolina at Chapel Hill · USGeorgia State University · USUniversity of California, Santa Barbara · US

Funding

UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Targeting Cortical Dynamics: Rational Design of Individualized Brain StimulationR01MH101547 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2013 to 2017
$2.2M
NIMH NIH HHS R01 MH101547NIMH NIH HHS R01MH101547NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

The frequency at which a stimulus is presented determines how it is interpreted. For example, a repeated image may be of less interest than an image that violates the prior sequence. This process involves integration of sensory information and internal representations of stimulus history, functions carried out in higher-order sensory areas such as the posterior parietal cortex (PPC). Thus far, there are few detailed reports investigating the single-neuron mechanisms for processing of stimulus presentation frequency in PPC. To address this gap in knowledge, we recorded PPC activity using 2-photon calcium imaging and electrophysiology during a visual oddball paradigm. Calcium imaging results reveal differentiation at the level of single neurons for frequent versus rare conditions which varied depending on whether the stimulus was preferred or non-preferred by the recorded neural population. Such differentiation of oddball conditions was mediated primarily by stimulus-independent adaptation in the frequent condition.

Indexed as

AnimalsElectrophysiological PhenomenaFemaleFerretsNeuronsParietal LobePhotic StimulationVisual Perception

Identifiers

PMID32811878
PMCPMC7435179
OpenAlexW3050596166

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.