ArticleNature communications2020
Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Local Trade-Offs Shape Flower Size Evolution Across Arabidopsis thaliana Distribution.Molecular ecology · 2026Article
- OsCPK9-mediated Thr105 phosphorylation activates OsCATC to enhance drought tolerance in rice.Journal of advanced research · 2026Article
- Correlational selection and genetic architecture shape the evolution of the leaf economics spectrum in a perennial grass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Divergent and stabilizing selection shape the phenotypic space of Arabidopsis thaliana.PLoS biology · 2025Article
- From Individual to Stand Performance in Hybrids: Challenging the Optimal Parental Genetic Distance.Evolutionary applications · 2025Article
- A basic framework to explain splice-site choice in eukaryotes.Nature communications · 2025Article
- The molecular basis of phenotypic evolution: beyond the usual suspects.Trends in genetics : TIG · 2024Review
- Ecological trade-offs drive phenotypic and genetic differentiation of Arabidopsis thaliana in Europe.Nature communications · 2024Article
- A dual-subcellular localized β-glucosidase confers pathogen and insect resistance without a yield penalty in maize.Plant biotechnology journal · 2024Article
- PlantPAN 4.0: updated database for identifying conserved non-coding sequences and exploring dynamic transcriptional regulation in plant promoters.Nucleic acids research · 2024Article
- Patterns and evolutionary consequences of pleiotropy.Annual review of ecology, evolution, and systematics · 2023Article
- Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns.PLoS biology · 2023Article
- Response of the organellar and nuclear (post)transcriptomes of Arabidopsis to drought.Frontiers in plant science · 2023Article
- Integrative analysis in Pinus revealed long-term heat stress splicing memory.The Plant journal : for cell and molecular biology · 2022Article
- Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity.PLoS genetics · 2022Article
- Quantifying splice-site usage: a simple yet powerful approach to analyze splicing.NAR genomics and bioinformatics · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Investigating the evolution of complex phenotypes and the underlying molecular bases of their variation is critical to understand how organisms adapt to their environment. Applying classical quantitative genetics on a segregating population derived from a Can-0xCol-0 cross, we identify the MADS-box transcription factor FLOWERING LOCUS M (FLM) as a player of the phenotypic variation in plant growth and color. We show that allelic variation at FLM modulates plant growth strategy along the leaf economics spectrum, a trade-off between resource acquisition and resource conservation, observable across thousands of plant species. Functional differences at FLM rely on a single intronic substitution, disturbing transcript splicing and leading to the accumulation of non-functional FLM transcripts. Associations between this substitution and phenotypic and climatic data across Arabidopsis natural populations, show how noncoding genetic variation at a single gene might be adaptive through pleiotropic effects.
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