Evidence map›Paper›PMID 32811826›Full record

ArticleNature communications2020

Influenza A virus is transmissible via aerosolized fomites.

Sima Asadi, Nassima Gaaloul Ben Hnia, Ramya S Barre, Anthony S Wexler, William D Ristenpart, Nicole M Bouvier

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sima AsadiDepartment of Chemical Engineering, University of California Davis, One Shields Ave., Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0001-8380-1564
Nassima Gaaloul Ben HniaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0003-0831-6168
Ramya S BarreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-8773-6349
Anthony S WexlerDepartment of Mechanical and Aerospace Engineering, University of California Davis, One Shields Ave., Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0003-1565-814X
William D RistenpartDepartment of Chemical Engineering, University of California Davis, One Shields Ave., Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0002-4935-6310
Nicole M BouvierDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA. nicole.bouvier@mssm.edu.ORCID http://orcid.org/0000-0002-4530-2841
Icahn School of Medicine at Mount Sinai · USUniversity of California, Davis · USPrinceton University · USQuality Research · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nicholas J. KENYON · 2015 to 2026
$26.0M
Quantifying Environmental Variables Affecting Airborne Influenza TransmissionR01AI110703 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOUVIER, NICOLE M. · 2015 to 2019
$2.0M
NIAID NIH HHS R01 AI110703NIEHS NIH HHS P30 ES023513
6 · The paper itself

Abstract

Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called "aerosolized fomites." In the guinea pig model of influenza virus transmission, we show that the airborne particulates produced by infected animals are mainly non-respiratory in origin. Surprisingly, we find that an uninfected, virus-immune guinea pig whose body is contaminated with influenza virus can transmit the virus through the air to a susceptible partner in a separate cage. We further demonstrate that aerosolized fomites can be generated from inanimate objects, such as by manually rubbing a paper tissue contaminated with influenza virus. Our data suggest that aerosolized fomites may contribute to influenza virus transmission in animal models of human influenza, if not among humans themselves, with important but understudied implications for public health.

Indexed as

FomitesInfluenza A virusParticulate MatterAerosolsAnimalsDisease Models, AnimalFemaleGuinea PigsHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsParticle SizeAerosolsParticulate Matter

Identifiers

PMID32811826
PMCPMC7435178
OpenAlexW3051453340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.