Evidence map›Paper›PMID 32811809›Full record

ArticleCell death & disease2020

Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice.

Giulia Dematteis, Gabrielė Vydmantaitė, Federico Alessandro Ruffinatti, Malak Chahin, Serena Farruggio, Elettra Barberis, Eleonora Ferrari, Emilio Marengo, Carla Distasi, Ramunė Morkūnienė and 8 more

Abstract read
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Giulia Dematteis *Department of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.
Gabrielė Vydmantaitė *Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Federico Alessandro RuffinattiDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.
Malak ChahinDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.
Serena FarruggioDepartment of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Elettra BarberisDepartment of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Eleonora FerrariCenter for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale, Novara, Italy.
Emilio MarengoDiSIT, University of Piemonte Orientale, Alessandria, Italy.
Carla DistasiDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.
Ramunė MorkūnienėDepartment of Drug Chemistry, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Armando A GenazzaniDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.
Mariagrazia GrilliDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.ORCID http://orcid.org/0000-0001-9165-5827
Elena GrossiniDepartment of Translational Medicine, University of Piemonte Orientale, Novara, Italy.ORCID http://orcid.org/0000-0002-3012-259X
Marco CorazzariCenter for Translational Research on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale, Novara, Italy.
Marcello ManfrediDepartment of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Dmitry LimDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy. dmitry.lim@uniupo.it.ORCID http://orcid.org/0000-0002-4316-2654
Aistė JekabsoneInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Aiste.Jekabsone@lsmuni.lt.
Laura TapellaDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale, Novara, Italy.ORCID http://orcid.org/0000-0002-8159-1628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of Alzheimer's disease (AD), a slowly-developing age-related neurodegenerative disorder, is a result of the action of multiple factors including deregulation of Ca

Indexed as

Alzheimer DiseaseAnimalsAstrocytesBrainCalciumEndoplasmic ReticulumEnergy MetabolismGlycolysisHippocampusHomeostasisHumansMiceMice, TransgenicMitochondriaNeuronsOxygen ConsumptionCalciumReactive Oxygen Species

Identifiers

PMID32811809
PMCPMC7434916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.