ArticleMicrobial cell factories2020
Metabolic engineering of Escherichia coli for L-malate production anaerobically.
Article in Microbial cell factories, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Decoding the HMO‒microbiome axis: bridging maternal milk to infant health outcomes.Gut microbes · 2026Review
- An anoxygenic photosynthesis-inspired dual biohybrid for light-enhanced chemical production.Science advances · 2026Article
- Enhanced anti-EpCAM ScFv production and reduced acetate overflow in a BW25113-derived E. coli strain with ArcA and Pka deletions.Microbial cell factories · 2025Article
- Production of hydrogen from crude glycerol via an integrated process of L-malate biosynthesis by Escherichia coli and photofermentation by Rhodobacter capsulatus.Microbial cell factories · 2025Article
- Forms and mechanisms for Escherichia coli long-term survival in silanol-humate gels.Archives of microbiology · 2025Article
- Deletion of succinic semialdehyde dehydrogenase sad and chromosomal expression of phosphoenolpyruvate carboxylase as metabolic requirements for improved production of 2,4-dihydroxybutyric acid via malyl-P pathway usingFrontiers in bioengineering and biotechnology · 2025Article
- Construction and Application of a Multienzyme System for Synthesis of L-malate.Applied biochemistry and biotechnology · 2024Article
- Periplasmic biomineralization for semi-artificial photosynthesis.Science advances · 2023Article
- Geobacter sulfurreducens metabolism at different donor/acceptor ratios.MicrobiologyOpen · 2022Article
- Toxicity and inhibition mechanism of gallic acid on physiology and fermentation performance of Escherichia coli.Bioresources and bioprocessing · 2022Article
- Microbial degradation and valorization of poly(ethylene terephthalate) (PET) monomers.World journal of microbiology & biotechnology · 2022Review
- Identification of Enzymatic Bottlenecks for the Aerobic Production of Malate from Glycerol by the Systematic Gene Overexpression of Anaplerotic Enzymes inInternational journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundL-malate is one of the most important platform chemicals widely used in food, metal cleaning, textile finishing, pharmaceuticals, and synthesis of various fine chemicals. Recently, the development of biotechnological routes to produce L-malate from renewable resources has attracted significant attention.
resultsA potential L-malate producing strain E. coli BA040 was obtained by inactivating the genes of fumB, frdABCD, ldhA and pflB. After co-overexpression of mdh and pck, BA063 achieved 18 g/L glucose consumption, leading to an increase in L-malate titer and yield of 13.14 g/L and 0.73 g/g, respectively. Meantime, NADH/NAD
conclusionsThe availability of NAD(H) was correlated positively with the glucose utilization rate and cellular metabolism capacities, and lower NADH/NAD
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