ArticleBMC infectious diseases2020
Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Pattern-based clinical recognition of diabetes-associatedFrontiers in cellular and infection microbiology · 2026Review
- Monoclonal Antibodies Can Aid in the Culture-Based Detection and Differentiation ofAntibodies (Basel, Switzerland) · 2025Article
- Mucormycosis Caused byJournal of fungi (Basel, Switzerland) · 2025Review
- Endotracheal Actinomycosis Combined With Mucormycosis: A Case Report and Literature Review.Respirology case reports · 2025Article
- Epidemiological Trends of Mucormycosis in Europe, Comparison with Other Continents.Mycopathologia · 2024Review
- Diverse Clinical Manifestations and Challenges of Mucormycosis: Insights From Serial Cases.Open forum infectious diseases · 2023Article
- First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras.Infectious disease reports · 2022Article
- A case of COVID-19-associated rhino-orbito-cerebral mucormycosis caused byFrontiers in cellular and infection microbiology · 2022Review
- Rhino-Orbital-Cerebral Mycosis and Extranodal Natural Killer or/and T-Cell Lymphoma, Nasal Type.Frontiers in medicine · 2022Article
- Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most common aetiological agents of mucormycosis are Rhizopus, Mucor, Apophysomyces and Lichtheimia. Apophysomyces is comparatively rare, as it has been reported in less than 3% of mucormycosis cases. The genus Apophysomyces includes six species, and only A. elegans, A. mexicanus, A. variabilis and A. ossiformis have been reported to cause infections in both immunocompetent and immunocompromised patients. CASE PRESENTATION: We present a case of a 46-year-old male patient with bilateral blepharoedema, corneal opacity in the left eye and poorly controlled diabetes mellitus. The patient was subjected to total maxillectomy, exenteration of the left orbit and treatment with liposomal amphotericin B. Direct mycological analysis with KOH 10% revealed hyaline, coenocytic, long and wide hyphae. Apophysomyces ossiformis was identified from maxillary biopsy using 18S-ITS1-5.8S-ITS2-28S rRNA gene amplification and sequencing. The patient requested to be transferred to another hospital to continue treatment, where he died on the ninth day after admittance.
conclusionTo the best of our knowledge, this is the first case of rhino-orbital mucormycosis due to A. ossiformis with a fatal outcome. This case reveals the need to identify the fungus causing mucormycosis with molecular methods to identify adequate treatment therapies for patients with this infection.
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