Evidence map›Paper›PMID 32811334›Full record

ArticleEmerging microbes & infections2020

Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice.

Yuan Yin, BeiBei Li, Linting Zhou, Jian Luo, Xueying Liu, Shilei Wang, Qun Lu, Wensong Tan, Ze Chen

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  7. An immunoinformatics approach for design and validation of multi-subunit vaccine againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yuan YinDepartment of Clinical Laboratory, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
BeiBei LiShanghai Institute of Biological Products, Shanghai, People's Republic of China.
Linting ZhouShanghai Institute of Biological Products, Shanghai, People's Republic of China.
Jian LuoShanghai Institute of Biological Products, Shanghai, People's Republic of China.
Xueying LiuShanghai Institute of Biological Products, Shanghai, People's Republic of China.
Shilei WangShanghai Institute of Biological Products, Shanghai, People's Republic of China.
Qun LuDepartment of Clinical Laboratory, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Wensong TanState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Ze ChenShanghai Institute of Biological Products, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0003-4717-0747
Biological E (India) · INEast China University of Science and Technology · CNHunan Normal University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nucleoprotein (NP) is a highly conserved internal protein of the influenza virus, a major target for universal influenza vaccine. Our previous studies have proven NP-based subunit vaccine can provide partial protection in mice. It is reported that the protein transduction domain (PTD) TAT protein from human immunodeficiency virus-1 (HIV-1) is able to penetrate cells when added exogenous protein and could effectively enhance the immune response induced by the exogenous protein. In present study, the recombinant protein TAT-NP, a fusion of TAT and NP was effectively expressed in

Indexed as

Administration, IntranasalAnimalsDogsEscherichia coliFemaleHEK293 CellsHumansImmunity, CellularImmunizationImmunoglobulin AImmunoglobulin GInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesMadin Darby Canine Kidney CellsMaleMiceImmunoglobulin AImmunoglobulin GInfluenza VaccinesNP protein, Influenza A virusNucleocapsid ProteinsRecombinant Fusion Proteinstat Gene Products, Human Immunodeficiency Viruscross-protectionInfluenza virusnucleoproteinprotein transduction domainuniversal vaccine

Identifiers

PMID32811334
PMCPMC8284974
OpenAlexW3052271924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.