ArticleProceedings. Biological sciences2020
Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function.
Article in Proceedings. Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Did Down-Regulated Instincts Enable Human Gene-Culture Coevolution?Evolutionary anthropology · 2025Review
- Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans.Heredity · 2025Article
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- Solutions to the fertility equation in beef embryo recipients.Animal reproduction · 2024Review
- Effect of MHC and inbreeding on disassortative reproduction: A data revisit, extension and inclusion of fertilization in sand lizards.Ecology and evolution · 2023Article
- Morphological and Molecular Bases of Male Infertility: A Closer Look at Sperm Flagellum.Genes · 2023Review
- Cryptic female choice within individual males - A neglected component of the postmating sexual selection?Journal of evolutionary biology · 2022Review
- Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.International journal of molecular sciences · 2022Article
- Female-induced selective modification of sperm protein SUMOylation-potential mechanistic insights into the non-random fertilization in humans.Journal of evolutionary biology · 2022Article
- Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility.Human reproduction (Oxford, England) · 2021Article
- Article
- Evolutionary consequences of environmental effects on gamete performance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Pronounced Postmating Response in the Drosophila Female Reproductive Tract Fluid Proteome.Molecular & cellular proteomics : MCP · 2021Article
- The Impact of NADPH Oxidase 5 Activity and Reactive Oxygen Species on Capacitated Human Sperm.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have demonstrated that women show pre-copulatory mating preferences for human leucocyte antigen (HLA)-dissimilar men. A fascinating, yet unexplored, possibility is that the ultimate mating bias towards HLA-dissimilar partners could occur after copulation, at the gamete level. Here, we explored this possibility by investigating whether the selection towards HLA-dissimilar partners occurs in the cervical mucus. After combining sperm and cervical mucus from multiple males and females (full factorial design), we found that sperm performance (swimming velocity, hyperactivation, and viability) was strongly influenced by the male-female combination. This indicates that sperm fertilization capability may be dependent on the compatibility between cervical mucus (female) and sperm (male). We also found that sperm viability was associated with partners' HLA dissimilarity, indicating that cervical mucus may selectively facilitate later gamete fusion between immunogenetically compatible partners. Together, these results provide novel insights into the female-mediated sperm selection (cryptic female choice) in humans and indicate that processes occurring after copulation may contribute to the mating bias towards HLA-dissimilar partners. Finally, by showing that sperm performance in cervical mucus is influenced by partners' genetic compatibility, the present findings may promote a deeper understanding of infertility.
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