Evidence map›Paper›PMID 32811187›Full record

ArticleAmyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis2021

Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.

Luke T Nelson, Ryan J Paxman, Jin Xu, Bill Webb, Evan T Powers, Jeffery W Kelly

Open access · hybridAbstract read
In one paragraph

Article in Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Luke T NelsonDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Ryan J PaxmanDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Jin XuDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Bill WebbCenter for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Evan T PowersDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-8185-8487
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-8943-3395
Scripps Research Institute · US

Funding

Probing the Biochemical Mechanisms of Amyloid DiseaseR01DK046335 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W · 1998 to 2025
$8.8M
Probing the biochemical mechanism of amyloid diseaseR37DK046335 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W · 2006 to 2015
$5.9M
NIDDK NIH HHS R01 DK046335NIDDK NIH HHS R37 DK046335
6 · The paper itself

Abstract

Transthyretin (TTR) tetramer dissociation is rate limiting for aggregation and subunit exchange. Slowing of TTR tetramer dissociation

Indexed as

AmyloidAmyloid Neuropathies, FamilialBenzoatesBenzoic AcidBenzoxazolesCardiomyopathiesDiflunisalHumansKineticsPrealbuminProtein AggregatesProtein BindingProtein MultimerizationProtein SubunitsPyrazolesTolcaponeacoramidisAmyloidBenzoatesBenzoic AcidBenzoxazolesDiflunisalPrealbuminProtein AggregatesProtein SubunitsPyrazolestafamidisTolcaponetransthyretin-related amyloid fibril protein, humanamyloid angiopathyhereditary transthyretin (TTR) amyloid cardiomyopathy (ATTRv-CM)Kinetic stabilisationleptomeningeal transthyretin (TTR) amyloidosissenile systemic amyloidosistransthyretin (TTR) central nervous system amyloidosistransthyretin (TTR) eye amyloidosisvitreous transthyretin (TTR) amyloidosisWild-type transthyretin (TTR) amyloid cardiomyopathy (ATTRwt-CM)

Identifiers

PMID32811187
PMCPMC7952025
OpenAlexW3057622720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.