Evidence map›Paper›PMID 32811149›Full record

ArticleJournal of the American Chemical Society2020

Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.

Savvas Louka, Sarah M Barry, Derren J Heyes, M Qadri E Mubarak, Hafiz Saqib Ali, Lona M Alkhalaf, Andrew W Munro, Nigel S Scrutton, Gregory L Challis, Sam P de Visser

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 99 citations in OpenAlex.

  1. A molecular description of plant cellulose biosynthesis inhibition.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. COInorganic chemistry · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.Journal of the American Chemical Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Savvas LoukaThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Sarah M BarryDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
Derren J HeyesThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
M Qadri E MubarakThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Hafiz Saqib AliThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Lona M AlkhalafDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
Andrew W MunroThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.ORCID 0000-0002-4642-180X
Nigel S ScruttonThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.ORCID 0000-0002-4182-3500
Gregory L ChallisDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0001-5976-3545
Sam P de VisserThe Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.ORCID 0000-0002-2620-8788
University of Manchester · GBUniversity of Warwick · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H006265/1Biotechnology and Biological Sciences Research Council BB/H006281/1
6 · The paper itself

Abstract

The cytochromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body related to biodegradation and biosynthesis. They typically act as mono-oxygenases; however, the recently discovered P450 subfamily TxtE utilizes O

Indexed as

BiocatalysisCytochrome P-450 Enzyme SystemDensity Functional TheoryFerric CompoundsModels, MolecularMolecular ConformationNitro CompoundsPeroxynitrous AcidCytochrome P-450 Enzyme SystemFerric CompoundsNitro CompoundsPeroxynitrous Acid

Identifiers

PMID32811149
PMCPMC7586343
OpenAlexW3072994615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.