Evidence map›Paper›PMID 32810975›Full record

ReviewZhongguo fei ai za zhi = Chinese journal of lung cancer2020

[CAR-T Immunotherapy and Non-small Cell Lung Cancer: Bottleneck and Dawn].

Li Zhang, Heng Li, Feiyue Zhang, Shuting Wang, Gaofeng Li

Open access · greenAbstract readReview
In one paragraph

Review in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Li ZhangDepartment of Thoracic Surgery, Yunnan Cancer Hospital, Kunming 650118, China.
Heng LiDepartment of Thoracic Surgery, Yunnan Cancer Hospital, Kunming 650118, China.
Feiyue ZhangDepartment of Thoracic Surgery, Yunnan Cancer Hospital, Kunming 650118, China.
Shuting WangDepartment of Thoracic Surgery, Yunnan Cancer Hospital, Kunming 650118, China.
Gaofeng LiDepartment of Thoracic Surgery, Yunnan Cancer Hospital, Kunming 650118, China.
Kunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the deeper understanding of the pathophysiology and pathogenesis of non-small cell lung cancer (NSCLC) which threatens human health, NSCLC treatment has entered a new era. Transition from traditional treatment based on surgery, radiotherapy and chemotherapy to individualized and precise targeted therapy and safer and more effective immunotherapy. Immune checkpoint inhibitor therapy has been approved as a first-line or second-line treatment for advanced NSCLC, and has achieved extraordinary clinical results. Meanwhile, other types of immunotherapy are rarely explored in NSCLC. Chimeric antigen receptor modified T cells (CAR-T cells) perform well in treating several hematological malignancies. However, it is not ideal for treating patients with solid tumors including NSCLC. This review aims to systematically explain the latest progress of CAR-T in the treatment of NSCLC, mainly including: CAR molecular target selection, CAR-T function enhancement and related toxicity management, as well as the difficulties and prospects of CAR-T treatment of NSCLC. It aims to open up new perspectives and unique ideas for the immunotherapy of NSCLC, and contribute to the building of tumor immunotherapy.
.

Indexed as

ImmunotherapyAnimalsCarcinoma, Non-Small-Cell LungHumansLung NeoplasmsReceptors, Chimeric AntigenT-LymphocytesReceptors, Chimeric AntigenChimeric antigen receptor modified T cellsLung neoplasmsTargetToxicity

Identifiers

PMID32810975
PMCPMC7583876
OpenAlexW3080627896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.