Is loss of perineuronal nets a critical pathological event in Alzheimer's disease?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer's Disease.Translational neurodegeneration · 2024
   Review
2. Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease.Molecular psychiatry · 2024
   Article
3. The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders.Life (Basel, Switzerland) · 2024
   Review
4. Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders.International journal of molecular sciences · 2024
   Review
5. Age-Dependent Sex Differences in Perineuronal Nets in anInternational journal of molecular sciences · 2023
   Article
6. GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo.Cellular and molecular life sciences : CMLS · 2023
   Article
7. HS, an Ancient Molecular Recognition and Information Storage Glycosaminoglycan, Equips HS-Proteoglycans with Diverse Matrix and Cell-Interactive Properties Operative in Tissue Development and Tissue Function in Health and Disease.International journal of molecular sciences · 2023
   Review
8. The fate of interneurons, GABABrain pathology (Zurich, Switzerland) · 2023
   Review
9. Regulation of the E/I-balance by the neural matrisome.Frontiers in molecular neuroscience · 2023
   Review
10. Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis.Cells · 2022
    Review
11. Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
12. The "Loss" of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight?Frontiers in integrative neuroscience · 2022
    Article

Corrections and comments

• Comment on
  Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain.2020

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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