ArticleInternational journal of biological macromolecules2020
Microwave-assisted extraction, characterization and immunomodulatory activity on RAW264.7 cells of polysaccharides from Trichosanthes kirilowii Maxim seeds.
Article in International journal of biological macromolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 57 citations in OpenAlex.
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- A Novel Polysaccharide from Blackened Jujube: Structural Characterization and Immunoactivity.Foods (Basel, Switzerland) · 2025Article
- Separation, Purification, Structural Characterization, and In Vitro Hypoglycemic Activity of Polysaccharides fromMolecules (Basel, Switzerland) · 2025Article
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- Structural Characterization and Antioxidant Activity of β-Glucans from Highland Barley Obtained with Ultrasonic-Microwave-Assisted Extraction.Molecules (Basel, Switzerland) · 2024Article
- Trichosanthis Semen and Zingiberis Rhizoma Mixture Ameliorates Lipopolysaccharide-Induced Memory Dysfunction by Inhibiting Neuroinflammation.International journal of molecular sciences · 2022Article
- Acetylation Modification, Characterization, and Anticomplementary Activity of Polysaccharides fromPolymers · 2022Article
- Purification, Structural Characterization and Immunomodulatory Effects of Polysaccharides fromMolecules (Basel, Switzerland) · 2021Article
- Characterization and Evaluation of the Pro-Coagulant and Immunomodulatory Activities of Polysaccharides fromACS omega · 2021Article
- Production, Characterization and Immunomodulatory Activity of an Extracellular Polysaccharide fromMarine drugs · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Microwave-assisted extraction of polysaccharides from Trichosanthes kirilowii Maxim seeds (TKMSP) was optimized using Response surface methodology (RSM) base on Central composite design (CCD). The optimum extraction conditions are detailed as follows: liquid-solid ratio 42 mL/g, extraction temperature 80 °C, microwave power 570 W, extraction time 26 min. Under this conditions, the mean value of TKMSP yield 2.43 ± 0.45% (n = 3), which was consistent closely with the predicted value (2.44%). The five polysaccharides (TKMSP-1, TKMSP-2, TKMSP-3, TKMSP-4 and TKMSP-5) were isolated from TKMSP by DEAE-52. TKMSP-1, TKMSP-2 and TKMSP-4 were common in containing Man, Rib, Rha, GluA, GalA, Glu, Gal, Xyl, Arab and Fuc. However, there was no Fuc in TKMSP-3, while TKMSP-5 lacked GluA, GalA and Fuc. UV-vis and FT-IR analysis combined with molecular weight determination further indicated that the five fractions were polydisperse polysaccharides. A significant difference was achieved in the structural characterization of these five fractions. TKMSP exhibited immunosuppressive activity on RAW264.7 cells. It can be applied as a potential immunosuppressant agent in medicine.
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