ArticleCell2020
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04953312 (Calprotectin Involvement in Emergency Hematopoiesis Observed in Severe COVID-19), which is not on this map. Cited by 564 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
564citing papers in PubMed, 3 pooled it
57.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Calprotectin Involvement in Emergency Hematopoiesis Observed in Severe COVID-19
Who cites it
564 citing papers in PubMed, 3 syntheses or guidelines pooled it, 906 citations in OpenAlex.
- Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection.Biochemical genetics · 2024Pooled it
- Elevated level of circulating calprotectin correlates with severity and high mortality in patients with COVID-19.Immunity, inflammation and disease · 2024Pooled it
- Identifying key genes related to inflammasome in severe COVID-19 patients based on a joint model with random forest and artificial neural network.Frontiers in cellular and infection microbiology · 2023Pooled it
- Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death.JCI insight · 2026Trial
- Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough disease.Nature communications · 2024Trial
- Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.Science advances · 2023Trial
- Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026Review
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- Single-cell RNA sequencing reveals intrinsic and microbiota-associated sex differences in murine lung.Mucosal immunology · 2026Article
- Neuromedin U 'innervation' reprograms myeloid immunosuppression in neuroendocrine prostate cancer.Oncogene · 2026Article
- Type I IFN dynamics orchestrate protective ICAM1iScience · 2026Article
- Immune-Based Cytokine Signatures of Prolonged Pandemic-Associated Chilblains.The Journal of infectious diseases · 2026Article
- Annotation-free phenotype prediction using knowledge-augmented clustering from single-cell RNA sequencing data.Briefings in bioinformatics · 2026Article
- Opposing Association of Lung Neutrophils and PD-L1Aging cell · 2026Article
- DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS-CoV-2 Respiratory Infection Compromise Inflammation and Cellular Metabolism.Journal of extracellular vesicles · 2026Article
- Sepsis associated with Clostridioides difficile infection carries similar mortality to sepsis of other origin: a propensity score-matched analysis.Scientific reports · 2026Observational
- Article
- Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID.Clinical proteomics · 2026Review
- Multidimensional single-cell analysis reveals immune dysfunction and inflammatory response in lymphatic malformations.Protein & cell · 2026Article
- Cross-coronavirus host susceptibility loci influence disease severity through immune mediators.bioRxiv : the preprint server for biology · 2026Article
504 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors at 8 institutions in 4 countries.
Aymeric SilvinINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Nicolas ChapuisUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service d'Hématologie Biologique, AP-HP, Hôpital Cochin, Paris 75014, France.
Garett DunsmoreINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Anne-Gaëlle GoubetINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Agathe DubuissonINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Lisa DerosaINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France; Département d'Oncologie Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Carole AlmireService d'Hématologie Biologique, AP-HP, Hôpital Cochin, Paris 75014, France.
Clémence HénonINSERM U981, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Olivier KosmiderUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service d'Hématologie Biologique, AP-HP, Hôpital Cochin, Paris 75014, France.
Nathalie DroinINSERM U1287, Gustave Roussy Cancer Campus, Villejuif 94800, France; INSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Philippe RameauINSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Cyril CatelainINSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Alexia AlfaroINSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Charles DussiauUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service d'Hématologie Biologique, AP-HP, Hôpital Cochin, Paris 75014, France.
Chloé FriedrichUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service d'Hématologie Biologique, AP-HP, Hôpital Cochin, Paris 75014, France.
Elise SourdeauService des Urgences, AP-HP, Hôpital Hôtel-Dieu, Paris 75014, France.
Nathalie MarinService de Médecine Intensive et Réanimation, AP-HP, Hôpital Cochin, Paris 75014, France.
Tali-Anne SzwebelService de Médecine Interne, AP-HP, Hôpital Cochin, Paris 75014, France.
Delphine CantinService des Urgences, AP-HP, Hôpital Hôtel-Dieu, Paris 75014, France.
Luc MouthonUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service de Médecine Interne, AP-HP, Hôpital Cochin, Paris 75014, France.
Didier BorderieService de Diagnostic Biologique Automatisé, AP-HP, Hôpital Cochin, Paris 75014, France.
Marc DelogerINSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Delphine BredelINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Severine MouraudINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Damien DrubayINSERM U1018, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Muriel AndrieuUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France.
Anne-Sophie LhonneurLaboratoire de Virologie, AP-HP, Hôpital Cochin, Paris 75014, France.
Véronique SaadaDépartement de Biologie et Pathologie, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Annabelle StoclinService de Réanimation Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Christophe WillekensINSERM U1287, Gustave Roussy Cancer Campus, Villejuif 94800, France; Département d'Hématologie, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Fanny PommeretDépartement d'Oncologie Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Frank GriscelliDépartement d'Oncologie Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France; Département de Biologie et Pathologie, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Lai Guan NgSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos Building #3-4, Biopolis, Singapore 138648, Singapore.
Zheng ZhangInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China.
Pierre BostSystems Biology Group, Department of Computational Biology and USR 3756, Institut Pasteur and CNRS, Paris 75015, France; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Ido AmitDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Fabrice BarlesiDépartement d'Oncologie Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Aurélien MarabelleINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France; Département d'Innovation Thérapeutique et d'Essais Précoces (DITEP), Gustave Roussy Cancer Campus, Villejuif 94800, France.
Frédéric PèneUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service de Médecine Intensive et Réanimation, AP-HP, Hôpital Cochin, Paris 75014, France.
Bertrand GachotService de Réanimation Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France.
Fabrice AndréDépartement d'Oncologie Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France; INSERM U981, Gustave Roussy Cancer Campus, Villejuif 94800, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre 94270, France.
Laurence ZitvogelINSERM U1015, Gustave Roussy Cancer Campus, Villejuif 94800, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre 94270, France; Centre d'Investigation Clinique - Biothérapie, INSERM CICBT1428, Villejuif 94800, France.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Immunos Building #3-4, Biopolis, Singapore 138648, Singapore; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore 169856, Singapore. Electronic address: florent_ginhoux@immunol.a-star.edu.sg.
Michaela FontenayUniversité de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris 75006, France; Service d'Hématologie Biologique, AP-HP, Hôpital Cochin, Paris 75014, France. Electronic address: michaela.fontenay@aphp.fr.
Eric SolaryINSERM U1287, Gustave Roussy Cancer Campus, Villejuif 94800, France; Service de Réanimation Médicale, Gustave Roussy Cancer Campus, Villejuif 94800, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre 94270, France. Electronic address: eric.solary@gustaveroussy.fr.
Centre National de la Recherche Scientifique · FRInserm · FRInstitut Gustave Roussy · FRHôpital Cochin · FRAgency for Science, Technology and Research · SGAssistance Publique – Hôpitaux de Paris · FRSouthern University of Science and Technology · CNWeizmann Institute of Science · IL
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with disease severity and whether markers of innate immunity discriminate high-risk patients. Thus, we performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells and detected disappearance of non-classical CD14
Indexed as
CoronavirusCoronavirus InfectionsPandemicsPneumonia, ViralBetacoronavirusCOVID-19Flow CytometryHumansLeukocyte L1 Antigen ComplexMonocytesMyeloid CellsProspective StudiesSARS-CoV-2Leukocyte L1 Antigen ComplexcalprotectinCOVID-19emergency myelopoiesismonocyte subsetsneutrophilsS100A8S100A9SARS-CoV-2type I interferon
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04953312ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.