ArticleCell2020
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Open access · bronzeAbstract read
In one paragraph
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 997 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
997citing papers in PubMed, 2 pooled it
31.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
997 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,580 citations in OpenAlex.
- A consensus immune dysregulation framework for sepsis and critical illnesses.Nature medicine · 2025Guideline
- Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections.Communications biology · 2025Pooled it
- Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death.JCI insight · 2026Trial
- Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.Nature aging · 2025Trial
- Monocyte exhaustion associated with systemic lupus erythematosus.Autoimmunity · 2026Article
- Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026Review
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- Immune dysregulation in the prostates of C57BL/6The Journal of pathology · 2026Article
- Granulocyte heterogeneity in immune-mediated and inflammatory diseases: insights from single-cell transcriptomic analyses.International immunology · 2026Review
- Acute viral respiratory infections are not associated with an increased IMMune Age indeX (IMMAX) four weeks after infection: a prospective observational cohort study.Immunity & ageing : I & A · 2026Article
- PhenoMapR: scalable mapping of sample phenotypes to single-cell, spatial, and bulk transcriptomics data.bioRxiv : the preprint server for biology · 2026Article
- Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade.eLife · 2026Article
- Development of a Novel Mouse Model of Severe Acute Pancreatitis with Pathological Features Recapitulating Human Disease.Digestive diseases and sciences · 2026Article
- Article
- Heterogeneity of Immunological, Coagulation and Complement Clustering to Viral Challenge and Clinical Relevance.International journal of molecular sciences · 2026Article
- Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.Nature communications · 2026Article
- Depth of neutrophil mobilization stratifies survival in ST-elevation myocardial infarction.Nature cardiovascular research · 2026Article
- Single-cell and spatial transcriptomic profiling reveals distinct immune landscapes in murine lungs infected with H1N1 versus H5N1 influenza viruses.Journal of virology · 2026Article
- Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma.Journal of neuroinflammation · 2026Article
- Coordinated expansion of CD163bioRxiv : the preprint server for biology · 2026Article
937 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
72 authors at 14 institutions in 2 countries.
Jonas Schulte-SchreppingLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Nico ReuschLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Daniela PaclikInstitute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Kevin BaßlerLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Stephan SchlickeiserInstitute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité, Universitätsmedizin Berlin, and Berlin Institute of Health (BIH) Berlin, Germany.
Bowen ZhangCentre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
Benjamin KrämerDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Tobias KrammerHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.
Sophia BrumhardDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Lorenzo BonaguroLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Elena De DomenicoGerman Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany.
Daniel WendischDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Martin GrasshoffCentre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
Theodore S KapellosLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Michael BeckstetteCentre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
Tal PechtLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Adem SaglamGerman Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany.
Oliver DietrichHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.
Henrik E MeiMass Cytometry Lab, DRFZ Berlin, a Leibniz Institute, Berlin, Germany.
Axel R SchulzMass Cytometry Lab, DRFZ Berlin, a Leibniz Institute, Berlin, Germany.
Claudia ConradDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Désirée KunkelFlow and Mass Cytometry Core Facility, Charité, Universitätsmedizin Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
Ehsan VafadarnejadHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.
Cheng-Jian XuCentre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Arik HorneLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Miriam HerbertLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Anna DrewsGerman Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany.
Charlotte ThibeaultDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Moritz PfeifferDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Stefan HippenstielDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL).
Andreas HockeDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL).
Holger Müller-RedetzkyDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Katrin-Moira HeimDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Felix MachleidtDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Alexander UhrigDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Laure Bosquillon de JarcyDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Linda JürgensDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Miriam StegemannDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Christoph R GlösenkampDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Hans-Dieter VolkInstitute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité, Universitätsmedizin Berlin, and Berlin Institute of Health (BIH) Berlin, Germany; Department of Immunology, Labor Berlin-Charité Vivantes, Berlin, Germany.
Christine GoffinetInstitute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany.
Markus LandthalerBerlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Emanuel WylerBerlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Philipp GeorgDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Maria SchneiderInstitute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Chantip Dang-HeineClinical Study Center (CSC), Charité, Universitätsmedizin Berlin, and Berlin Institute of Health, Berlin, Germany.
Nick NeuwingerDepartment of Immunology, Labor Berlin-Charité Vivantes, Berlin, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Kai KappertDepartment of Immunology, Labor Berlin-Charité Vivantes, Berlin, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Rudolf TauberDepartment of Immunology, Labor Berlin-Charité Vivantes, Berlin, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Victor CormanInstitute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Jan RaabeDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Kim Melanie KaiserDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Michael To VinhDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Gereon RiekeDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Christian MeiselInstitute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; Department of Immunology, Labor Berlin-Charité Vivantes, Berlin, Germany.
Thomas UlasGerman Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany.
Matthias BeckerGerman Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany.
Robert GeffersGenome Analytics, Helmholtz-Center for Infection Research (HZI), Braunschweig, Germany.
Martin WitzenrathDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL).
Christian DrostenInstitute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; German Center for Infection Research (DZIF).
Norbert SuttorpDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL).
Christof von KalleClinical Study Center (CSC), Charité, Universitätsmedizin Berlin, and Berlin Institute of Health, Berlin, Germany.
Florian KurthDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; I. Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
Kristian HändlerGerman Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany.
Joachim L SchultzeLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany. Electronic address: j.schultze@uni-bonn.de.
Anna C AschenbrennerLife and Medical Sciences (LIMES) Institute, University of Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Yang LiCentre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Jacob NattermannDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany; German Center for Infection Research (DZIF).
Birgit SawitzkiInstitute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Antoine-Emmanuel SalibaHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.
Leif Erik SanderDepartment of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL).
Deutsche COVID-19 OMICS Initiative (DeCOI)
Charité - Universitätsmedizin Berlin · DEUniversity of Bonn · DEUniversity Hospital Bonn · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEGerman Center for Lung Research · DEHelmholtz Institute for RNA-based Infection Research · DEVivantes Klinikum · DEMax Delbrück Center · DEMedizinische Hochschule Hannover · DERadboud University Nijmegen · NLLeibniz Association · DEGerman Center for Infection Research · DEHelmholtz Centre for Infection Research · DEUniversität Hamburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DR
Indexed as
MyelopoiesisAdultAgedCD11 AntigensCells, CulturedCoronavirus InfectionsCOVID-19FemaleHLA-DR AntigensHumansMaleMiddle AgedMyeloid CellsPandemicsPneumonia, ViralProteomeCD11 AntigensHLA-DR AntigensProteomeCOVID-19dysfunctional neutrophilsemergency myelopoiesisimmune profilingmass cytometrymonocytesneutrophilsSARS-CoV-2scRNA-seq
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.