ArticleNeuron2020
Slow Drift of Neural Activity as a Signature of Impulsivity in Macaque Visual and Prefrontal Cortex.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
82 citing papers in PubMed, 140 citations in OpenAlex.
- Prioritized nonlinear modeling of shared dynamics across neural populations.Journal of neural engineering · 2026Article
- Trial-by-trial fluctuations in decision criterion shape confidence.Nature human behaviour · 2026Article
- Manifold-constrained plasticity enables stable learning in recurrent neural circuits.PLoS computational biology · 2026Article
- Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys.bioRxiv : the preprint server for biology · 2026Article
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Addressing degeneracy in rodent studies of cognition.Current opinion in neurobiology · 2026Review
- Premotor cortex hemodynamic responses primarily reflect perceptual rather than specific motor aspects of decision making.PLoS biology · 2026Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.Nature communications · 2026Article
- Linking reaction time variability to physiological markers of arousal across timescales.bioRxiv : the preprint server for biology · 2026Article
- The role of the locus coeruleus in eye movements during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- A Population Coupling Model Identifies Reduced Propagation from V1 to Higher Visual Areas During Locomotion.bioRxiv : the preprint server for biology · 2026Article
- Uncovering Dynamic Neural Information Flow with Continuous-Time Weighted Dynamic Bayesian Networks.bioRxiv : the preprint server for biology · 2026Article
- Convergence of Cortical and Thalamic Origins of Free Behavior Modulation of Mouse Primary Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Spiking neural networks provide accurate and time-efficient models for whisker stimulus classification of the awake mouse.Frontiers in neuroscience · 2026Article
- Brain-computer interfaces as a causal probe for scientific inquiry.Trends in cognitive sciences · 2026Review
- Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Parietal cortex is causally required for state-dependent decisions.Cell reports · 2025Article
- Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
An animal's decision depends not only on incoming sensory evidence but also on its fluctuating internal state. This state embodies multiple cognitive factors, such as arousal and fatigue, but it is unclear how these factors influence the neural processes that encode sensory stimuli and form a decision. We discovered that, unprompted by task conditions, animals slowly shifted their likelihood of detecting stimulus changes over the timescale of tens of minutes. Neural population activity from visual area V4, as well as from prefrontal cortex, slowly drifted together with these behavioral fluctuations. We found that this slow drift, rather than altering the encoding of the sensory stimulus, acted as an impulsivity signal, overriding sensory evidence to dictate the final decision. Overall, this work uncovers an internal state embedded in population activity across multiple brain areas and sheds further light on how internal states contribute to the decision-making process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.