ArticleJournal of cellular and molecular medicine2020
Activation of ER stress signalling increases mortality after a major trauma.
Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Beyond diabetes: harnessing the power of metformin in burn care.Critical care (London, England) · 2025Review
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- β-Adrenergic blockade attenuates adverse adipose tissue responses after burn.Journal of molecular medicine (Berlin, Germany) · 2024Article
- Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims.Communications biology · 2023Article
- Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model.Blood advances · 2023Article
- [Effects and mechanism of diammonium glycyrrhizinate on liver injury in severely scalded rats].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Tissue Damage, Not Infection, Triggers Hepatic Unfolded Protein Response in an Experimental Rat Peritonitis Model.Frontiers in medicine · 2022Article
- Dynamic regulation of mitochondrial-endoplasmic reticulum crosstalk during stem cell homeostasis and aging.Cell death & disease · 2021Review
- Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice.Clinical and translational medicine · 2021Article
- Interleukin-6 blockade, a potential adjunct therapy for post-burn hypermetabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer.Journal of Cancer · 2021Review
- Activation of ER stress signalling increases mortality after a major trauma.Journal of cellular and molecular medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The endoplasmic reticulum (ER) adapts to stress by activating a signalling cascade known as the ER stress response. While ER stress signalling is a central component of the cellular defence against environmental insult, persistent activation is thought to contribute to the progression of various metabolic complications via loss of protein function and cell death. Despite its importance however, whether and how ER stress impacts morbidity and mortality in conditions of hypermetabolism remain unclear. In this study, we discovered that chronic ER stress response plays a role in mediating adverse outcomes that occur after major trauma. Using a murine model of thermal injury, we show that induction of ER stress with Tunicamycin not only increased mortality but also resulted in hepatic damage and hepatic steatosis. Importantly, post-burn treatment with chaperone ER stress inhibitors attenuated hepatic ER stress and improved organ function following injury. Our study identifies ER stress as a potential hub of the signalling network affecting multiple aspects of metabolism after major trauma and as a novel potential molecular target to improve the clinical outcomes of severely burned patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.