SynthesisPloS one2020
Antibiotic dosage prescribed in oral implant surgery: A meta-analysis of cross-sectional surveys.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Is routine antibiotic prophylaxis warranted in dental implant surgery to prevent early implant failure? - a systematic review.BMC oral health · 2024Pooled it
- Short implants compared to regular dental implants after bone augmentation in the atrophic posterior mandible: umbrella review and meta-analysis of success outcomes.International journal of implant dentistry · 2023Pooled it
- Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials.Clinical oral investigations · 2022Pooled it
- Effects of clindamycin and amoxycillin as prophylaxis against early implant failure: double-blinded randomized clinical trial.Clinical oral investigations · 2024Trial
- The effect of preoperative clindamycin in reducing early oral implant failure: a randomised placebo-controlled clinical trial.Clinical oral investigations · 2023Trial
- A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials.International journal of implant dentistry · 2022Trial
- Do postoperative antibiotics influence one-year peri-implant crestal bone remodelling and morbidity? A double-blinded randomized clinical trial.Clinical oral implants research · 2021Trial
- Influence of Amoxicillin Dosage and Time of Administration on Postoperative Complications After Impacted Third Molar Surgery: A Randomized, Double-Blind, Controlled Clinical Trial.Antibiotics (Basel, Switzerland) · 2025Article
- Optimal Duration of Antibiotic Therapy for Space Infections in the Maxillofacial Region: A Systematic Review.Craniomaxillofacial trauma & reconstruction · 2025Review
- Use of antibiotic prophylaxis in conjunction with dental implant surgery in Sweden- A cross-sectional study.BMC oral health · 2025Article
- Comparing the Impact of Pre-Operative Antibiotics on the Outcomes of Immediately Placed Dental Implants: A Retrospective Multi-Center Study.Methods and protocols · 2025Article
- Comparative Effect of Different Preoperative Antibiotics on Dental Implant Failure: A Retrospective Cohort Study.International dental journal · 2025Article
- Dentists' attitudes and prescription practices for analgesics and antibiotics in Kirkuk Governorate, Iraq.Journal of medicine and life · 2023Article
- Antibiotic prophylaxis dysregulates dental implant placement surgery-induced osteoimmune wound healing and attenuates the alveolar bone-implant interface in mice.Journal of clinical periodontology · 2023Article
- Efficacy and safety of using antibiotics to prevent post-operative complications in oral implant treatment: evidence-based review.BDJ open · 2023Review
- Comparative Efficacy of Different Amoxicillin Dosing Regimens in Preventing Early Implant Failure-A Systematic Review with Network Meta-Analysis.Antibiotics (Basel, Switzerland) · 2023Review
- Is Antibiotic Prophylaxis Necessary before Dental Implant Procedures in Patients with Orthopaedic Prostheses? A Systematic Review.Antibiotics (Basel, Switzerland) · 2022Review
- The compliance of surgical prophylactic antibiotics with standard protocols in Imam Reza teaching hospital of Birjand, Iran.Iranian journal of microbiology · 2021Article
- Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2021Review
- Antibiotic Therapy in Dentistry.International journal of dentistry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the dosage and types of antibiotics prescribed in oral implant surgery, compare them among the different subpopulations (country and prescription regimens) and against the evidence-based recommended dosage: a 2-gram single preoperative dose of amoxicillin. A meta-analysis of cross-sectional surveys was conducted, which reports the overall dosage (and type) of antibiotics prescribed in combination with implant placement. PubMed, Cochrane, Science, Direct, and EMBASE via OVID were searched until April 2019. Three reviewers independently undertook data extraction and risk of bias assessment. The outcome variable was set on the average of prophylactic antibiotics prescribed per oral implant surgery. Overall, 726 participants from five cross-sectional surveys, representing five different countries were finally included. Amoxicillin was the most prescribed antibiotic. On average, 10,724 mg of antibiotics were prescribed per implant surgery. This average was significantly (p<0.001) higher than 2,000 mg. Overall, amoxicillin doses were significantly higher than 2,000 mg (9,700 mg, p<0.001). All prescribed amoxicillin regimens independently contained more than 2,000 mg, including those comprising only preoperative amoxicillin (2,175 mg, p = 0.006). Exclusive preoperative antibiotic regimens were the only subgroup with prescription dosages below this threshold (p = 0.091). Significant variations in antibiotic prescriptions were found among different countries and antibiotic regimens (p<0.001). In conclusion, the average dose of antibiotics prescribed per oral implant surgery was larger than the evidence-based recommended dose in healthy patients and straightforward conditions. In addition, variations in the average antibiotic dosages were found among different countries and prescription regimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.