SynthesisJournal of patient safety2020
The Effect of Opioid Stewardship Interventions on Key Outcomes: A Systematic Review.
Synthesis in Journal of patient safety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Comparative risk of psychiatric comorbidities associated with codeine and tramadol in patients with hip osteoarthritis: a nationwide population-based cohort study.Journal of global health · 2026Article
- Organizational Factors that Impact Trust in Healing Relationships: A Qualitative Study.Journal of general internal medicine · 2025Article
- Review
- Evaluating Postoperative Opioid Prescription Fills and Refills for Adolescents Undergoing Surgery.Journal of pediatric surgery · 2025Article
- Influence of Implementing an Opioid Stewardship Team in the Primary Care Setting.Hospital pharmacy · 2024Article
- Article
- Observational
- Opioid use in cancer patients compared with noncancer pain patients in a veteran population.JNCI cancer spectrum · 2024Article
- Trajectories and predictors of high-occurrence pain flares in ambulatory cancer patients on opioids.JNCI cancer spectrum · 2024Article
- Medicines stewardship.Australian prescriber · 2023Review
- What is "Opioid Stewardship"? An Overview of Current Definitions and Proposal for a Universally Acceptable Definition.Journal of pain research · 2023Review
- Factors That Affect Opioid Quality Improvement Initiatives in Primary Care: Insights from Ten Health Systems.Joint Commission journal on quality and patient safety · 2023Article
- Healthcare professionals' perspectives on the use of medicinal cannabis to manage chronic pain: A systematic search and narrative review.Pain practice : the official journal of World Institute of Pain · 2022Review
- Data-driven approach to implementation mapping for the selection of implementation strategies: a case example for risk-aligned bladder cancer surveillance.Implementation science : IS · 2022Article
- Interventions for physician prescribers of opioids for chronic non-cancer pain: protocol for an overview of systematic reviews.BMJ open · 2022Article
- Evaluating the Effects of Opioid Prescribing Policies on Patient Outcomes in a Safety-net Primary Care Clinic.Journal of general internal medicine · 2022Article
- Trends in potentially inappropriate opioid prescribing and associated risk factors among Korean noncancer patients prescribed non-injectable opioid analgesics.Therapeutic advances in drug safety · 2022Article
- Opioid prescribing among new users for non-cancer pain in the USA, Canada, UK, and Taiwan: A population-based cohort study.PLoS medicine · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe sought to identify potential patient safety practices to reduce high-risk opioid prescribing.
methodsWe conducted a systematic review of the literature to identify opioid stewardship (OS) strategies implemented in primary care and other settings. Included studies evaluated an OS strategy or a multicomponent OS initiative to address potential harms of opioids and used experimental or quasi-experimental designs.
resultsWe identified 14 studies and 1 systematic review that met inclusion criteria. Most studies examined multicomponent OS interventions, which often consisted of guideline-recommended clinical interventions or care processes (e.g., use urine drug screening, check Prescription Drug Monitoring Program), as well as implementation strategies (e.g., dashboards, audit and feedback). Most studies examined the effect of OS interventions on reducing the potential risks of opioids with judicious prescribing and guideline-concordant care (e.g., reduce inappropriate high opioid dosages, avoid co-prescribing opioids and benzodiazepines, use urine drug screening, treatment agreements).
conclusionsThe strength of the evidence is low to moderate that OS efforts decrease numbers of opioid prescriptions, proportion of patients on long-term opioids, or days' supply. The strength of the evidence for OS initiatives producing significant reductions in opioid dosages was moderate. Future research is needed on the effectiveness of OS interventions, particularly studies with experimental designs and in diverse settings within the health care system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.