Evidence map›Paper›PMID 32809903›Full record

ReviewJournal of the American Heart Association2020

Impact of Interatrial Shunts on Invasive Hemodynamics and Exercise Tolerance in Patients With Heart Failure.

Jan M Griffin, Barry A Borlaug, Jan Komtebedde, Sheldon E Litwin, Sanjiv J Shah, David M Kaye, Elke Hoendermis, Gerd Hasenfuß, Finn Gustafsson, Emil Wolsk and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Transcatheter interventions for heart failure.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023
    Review
  11. Review
  12. Update on Atrial Shunt Therapy for Treatment of Heart Failure.Structural heart : the journal of the Heart Team · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Device Therapy in Chronic Heart Failure: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 5 countries.

Jan M GriffinNew York Presbyterian Hospital New York NY USA.
Barry A BorlaugDepartment of Cardiovascular Medicine Mayo Clinic Rochester MN USA.
Jan KomtebeddeCorvia Medical, Inc. Tewksbury MA USA.
Sheldon E LitwinMedical University of South Carolina, Charleston South Carolina. Ralph H. Johnson VA Medical Center Charleston SC USA.
Sanjiv J ShahDivision of Cardiology Northwestern University Chicago IL USA.
David M KayeDepartment of Cardiology Alfred Hospital Melbourne Australia.
Elke HoendermisUniversity Medical Center Groningen the Netherlands.
Gerd HasenfußGeorg-August Universität, Heart Centre Gottingen Germany.
Finn GustafssonDepartment of Cardiology Rigshospitalet, Copenhagen Denmark.
Emil WolskDepartment of Cardiology Rigshospitalet, Copenhagen Denmark.
Nir UrielNew York Presbyterian Hospital New York NY USA.
Daniel BurkhoffCardiovascular Research Foundation New York NY USA.
NewYork–Presbyterian Hospital · USRigshospitalet · DKCardiovascular Research Foundation · USCorvia Medical (United States) · USMayo Clinic in Arizona · USMedical University of South Carolina · USNorthwestern University · USThe Alfred Hospital · AUUniversity Medical Center Groningen · NLUniversity of Göttingen · DE

Funding

Study of Cardiac Mechanics in Systemic HypertensionR01HL107577 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHAH, SANJIV J · 2011 to 2019
$4.1M
Machine learning for the automated identification and tracking of rare myocardial diseasesR01HL140731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MACRAE, CALUM A., SHAH, SANJIV J · 2018 to 2021
$2.8M
A Systems Biology Approach to Predicting Bleeding in HemophiliaR01HL120728 · NHLBI · COLORADO SCHOOL OF MINES · PI DI PAOLA, JORGE A, FOGELSON, AARON L · 2014 to 2018
$2.7M
Precision Medicine for Dilated Cardiomyopathy—Novel Assessment of Cardiac Mechanics via Speckle Tracking Echocardiography to Identify Early PhenotypesR01HL149423 · NHLBI · OHIO STATE UNIVERSITY · PI HERSHBERGER, RAY E., KINNAMON, DANIEL DAVIS · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL107577NHLBI NIH HHS R01 HL120728NHLBI NIH HHS R01 HL140731NHLBI NIH HHS R01 HL149423
6 · The paper itself

Abstract

Approximately 50% of patients with heart failure have preserved ejection fraction. Although a wide variety of conditions cause or contribute to heart failure with preserved ejection fraction, elevated left ventricular filling pressures, particularly during exercise, are common to all causes. Acute elevation in left-sided filling pressures promotes lung congestion and symptoms of dyspnea, while chronic elevations often lead to pulmonary vascular remodeling, right heart failure, and increased risk of mortality. Pharmacologic therapies, including neurohormonal modulation and drugs that modify the nitric oxide/cyclic GMP-protein kinase G pathway have thus far been limited in reducing symptoms or improving outcomes in patients with heart failure with preserved ejection fraction. Hence, alternative means of reducing the detrimental rise in left-sided heart pressures are being explored. One proposed method of achieving this is to create an interatrial shunt, thus unloading the left heart at rest and during exercise. Currently available studies have shown 3- to 5-mm Hg decreases of pulmonary capillary wedge pressure during exercise despite increased workload. The mechanisms underlying the hemodynamic changes are just starting to be understood. In this review we summarize results of recent studies aimed at elucidating the potential mechanisms of improved hemodynamics during exercise tolerance following interatrial shunt implantation and the current interatrial shunt devices under investigation.

Indexed as

AdultAgedAged, 80 and overCardiac OutputCase-Control StudiesCyclic GMP-Dependent Protein KinasesExerciseExercise ToleranceHeart AtriaHeart FailureHemodynamicsHumansMiddle AgedNitric OxideProstheses and ImplantsPulmonary Wedge PressureCyclic GMP-Dependent Protein KinasesNitric Oxideexerciseexercise capacityinteratrialshunt

Identifiers

PMID32809903
PMCPMC7660772
OpenAlexW3049489309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.