ArticleMolecular and cellular biology1988
Comparison of the structure and cell cycle expression of mRNAs encoded by two histone H3-H4 loci in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Defective transfer of parental histone decreases frequency of homologous recombination by increasing free histone pools in budding yeast.Nucleic acids research · 2024Article
- Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a Model.Journal of fungi (Basel, Switzerland) · 2023Review
- Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size.Molecular cell · 2021Article
- Transcription coordinates histone amounts and genome content.Nature communications · 2021Article
- A CRISPR-Cas9 based shuffle system for endogenous histone H3 and H4 combinatorial mutagenesis.Scientific reports · 2021Article
- Loss of chromatin structural integrity is a source of stress during aging.Human genetics · 2020Review
- Cellular response to moderate chromatin architectural defects promotes longevity.Science advances · 2019Article
- Article
- Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast.Journal of visualized experiments : JoVE · 2017Article
- The Major Replicative Histone Chaperone CAF-1 Suppresses the Activity of the DNA Mismatch Repair System in the Cytotoxic Response to a DNA-methylating Agent.The Journal of biological chemistry · 2016Article
- Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair.Genes & development · 2016Article
- Article
- Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway.Nucleic acids research · 2012Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.Biochimica et biophysica acta · 2012Article
- Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae.Genetics · 2010Article
- Article
- Differential regulation of repeated histone genes during the fission yeast cell cycle.Nucleic acids research · 2007Article
- Multiple independent evolutionary solutions to core histone gene regulation.Genome biology · 2006Article
- Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The haploid genome of Saccharomyces cerevisiae contains two nonallelic sets of histone H3 and H4 gene pairs, termed the copy I and copy II loci. The structures of the mRNA transcripts from each of these four genes were examined by nuclease protection and primer extension mapping. For each gene, several species of mRNAs were identified that differed in the lengths of their 5' and 3' untranslated regions. The cell cycle accumulation pattern of the H3 and H4 mRNAs was determined in cells from early-exponential-growth cultures fractionated by centrifugal elutriation. The RNA transcripts from all four genes were regulated with the cell division cycle, and transcripts from the nonallelic gene copies showed tight temporal coordination. Cell cycle regulation did not depend on selection of a particular histone mRNA transcript since the ratio of the multiple species from each gene remained the same across the division cycle. Quantitative measurements showed significant differences in the amounts of mRNA expressed from the two nonallelic gene sets. The mRNAs from the copy II H3 and H4 genes were five to seven times more abundant than the mRNAs from the copy I genes. There was no dosage compensation in the steady-state levels of mRNA when either set of genes was deleted. In particular, there was no increase in the amount of copy I H3 or H4 transcripts in cells in which the high-abundance copy II genes were deleted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.