ArticleHippocampus2020
Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation.
Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- New information triggers prospective codes to adapt for flexible navigation.Nature communications · 2025Article
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Pausing and reorienting behaviors enhance the performance of a spatial working memory task.Behavioural brain research · 2023Article
- Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.Cell reports · 2023Article
- Multiple-Timescale Representations of Space: Linking Memory to Navigation.Annual review of neuroscience · 2022Review
- The ventral midline thalamus coordinates prefrontal-hippocampal neural synchrony during vicarious trial and error.Scientific reports · 2022Article
- Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.PLoS biology · 2021Article
- Spatial Representations in Rat Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Navigating for reward.Nature reviews. Neuroscience · 2021Review
- The Radically Embodied Conscious Cybernetic Bayesian Brain: From Free Energy to Free Will and Back Again.Entropy (Basel, Switzerland) · 2021Article
- Article
- A Machine Learning Approach for Detecting Vicarious Trial and Error Behaviors.Frontiers in neuroscience · 2021Article
- Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision-making systems.International review of neurobiology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Deliberation is thought to involve the internal simulation of the outcomes of candidate actions, the valuation of those outcomes, and the selection of the actions with the highest expected value. While it is known that deliberation involves prefrontal cortical areas, specifically the dorsomedial prefrontal cortex (dmPFC), as well as the hippocampus (HPC) and other brain regions, how these areas process prospective information and select actions is not well understood. We recorded simultaneously from ensembles in dmPFC and CA1 of dorsal HPC in rats during performance of a spatial contingency switching task, and examined the relationships between spatial and reward encoding in these two areas during deliberation at the choice point. We found that CA1 and dmPFC represented either goal locations or the current position simultaneously, but that when goal locations were encoded, HPC and dmPFC did not always represent the same goal location. Ensemble activity in dmPFC predicted when HPC would represent goal locations, but on a broad timescale on the order of seconds. Also, reward encoding in dmPFC increased during hippocampal theta cycles where CA1 ensembles represented the goal location. These results suggest that dmPFC and HPC share prospective information during deliberation, that dmPFC may influence whether HPC represents prospective information, and that information recalled about goal locations by HPC may be integrated into dmPFC reward representations on fast timescales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.